Bioactive polymers XXXIII. Synthesis and evaluation of some pharmacological chapactepistics of chloramphenicol immobilized on Biozan R

The coupling of chloramphenicol on Biozan R (Hercules) by activation with dicyclohexylcarbodiimide was studied. The esterification is influenced by the chloramphenicol/dicyclohexylcarbodiimide ratio, concentration of the reactants and reaction time. The Biozan R-chloramphenicol system containing 15% chloramphenicol was used to obtain ophthalmic ointments. They were studied from the point of view of their physicochemical and biological properties. Tests were performed on animals and volunteers to establish the ophthalmic tolerance; some clinical observations on treated eyes were also made.