The promotion of neurological recovery in an intracerebral hemorrhage model using fibrin-binding brain derived neurotrophic factor
Source abstract
Abstract
Brain derived neurotrophic factor (BDNF) has been shown to ameliorate recovery after intracerebral hemorrhage (ICH). The injured brain tissue after ICH is surrounded by hematoma formed from hemorrhage. Fibrin is abundant in hematoma, which could be a binding target for BDNF. In this work, we have fused a fibrin-binding domain (FBD) to BDNF (FBD-BDNF), and results demonstrate that FBD-BDNF has specific binding ability to fibrin and is retained in hematoma. Using the rat ICH model induced by bacterial collagenase, injected FBD-BDNF has been concentrated and retained at the hematoma. FBD has facilitated BDNF to exert targeting neuroprotective effect to the injured brain tissue around the hematoma after ICH. FBD-BDNF has significantly reduced the hemotoma volume, reduced tissue loss, promoted neural regeneration, and improved the rat behavioral performance.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Intracerebral and Subarachnoid Hemorrhage Research · Nerve injury and regeneration · Spinal Hematomas and Complications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (46)
Show source-provided references
1. Guidelines for the management of spontaneous intracerebral hemorrhage: a statement for healthcare professionals from a special writing group of the stroke council, American heart association10.1161/01.STR.30.4.905 ↗
2. Treatment of intracerebral haemorrhage10.1016/S1474-4422(05)70195-2 ↗
3. Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the international surgical trial in intracerebral haemorrhage (STICH): a randomised trial10.1016/S0140-6736(05)70233-6 ↗
4. Neurodegeneration of substantia nigra accompanied with macrophage/microglia infiltration after intrastriatal hemorrhage10.1016/S0168-0102(03)00065-8 ↗
5. Death and functional outcome after spontaneous intracerebral hemorrhage. A prospective study of 166 cases using multivariate analysis10.1161/01.STR.22.1.1 ↗
6. The therapeutic potential of neurotrophic factors in the treatment of Parkinson’s disease10.1006/exnr.1993.1181 ↗
7. Expression of neurotrophic factors in neonatal rats after peripheral inflammation
8. Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor10.1006/exnr.1998.6878 ↗
9. Actions of neurotrophic factors and their signaling pathways in neuronal survival and axonal regeneration10.1385/MN:33:2:155 ↗
10. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia10.1038/nn1166 ↗
11. BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis10.1016/j.pneurobio.2005.06.003 ↗
12. IGF-1 and BDNF promote chick bulbospinal neurite outgrowth in vitro10.1016/j.ijdevneu.2005.07.003 ↗
13. BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury10.1523/JNEUROSCI.2769-09.2009 ↗
14. Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs10.1002/cne.903420302 ↗
15. Linear ordered collagen scaffolds loaded with collagen-Binding brain-derived neurotrophic factor improve the recovery of spinal cord injury in rats10.1089/ten.tea.2008.0506 ↗
16. Improved neovascularization and wound repair by targeting human basic fibroblast growth factor (bFGF) to fibrin10.1007/s00109-008-0372-9 ↗
17. Promotion of peripheral nerve growth by collagen scaffolds loaded with collagen-targeting human nerve growth factor-beta10.1002/jbm.a.31417 ↗
18. Collagen scaffolds loaded with collagen-binding NGF-beta accelerate ulcer healing10.1002/jbm.a.32445 ↗
19. Collagen membranes loaded with collagen-binding human PDGF-BB accelerate wound healing in a rabbit dermal ischemic ulcer model10.1080/08977190701803885 ↗
20. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction10.1161/CIRCULATIONAHA.108.800565 ↗
21. Structural origins of fibrin clot rheology10.1016/S0006-3495(99)77113-4 ↗
22. Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system10.1016/S0021-9258(19)39298-1 ↗
23. The lysine binding sites of human plasminogen. Evidence for a critical tryptophan in the binding site of kringle 410.1016/S0021-9258(19)68573-X ↗
24. The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain10.1016/S0021-9258(18)89800-3 ↗
25. Chromatographic methods for the isolation of, and refolding of proteins from, Escherichia coli inclusion bodies10.1006/prep.2002.1624 ↗
26. Erythropoietin promotes neurological recovery after intracerebral haemorrhage in rats10.1111/j.1747-4949.2009.00292.x ↗
27. Long-term effect of HU-211, a novel non-competitive NMDA antagonist, on motor and memory functions after closed head injury in the rat10.1016/0006-8993(94)01433-I ↗
28. Asymmetrical motor behavior in rats with unilateral striatal excitotoxic lesions as revealed by the elevated body swing test10.1016/0006-8993(95)00150-O ↗
29. Use-dependent structural events in recovery of function
30. Expression of GAP-43, a rapidly transported growth-associated protein, and class II beta tubulin, a slowly transported cytoskeletal protein, are coordinated in regenerating neurons10.1523/JNEUROSCI.09-03-00893.1989 ↗
31. New horizons for primary intracerebral hemorrhage treatment: experience from preclinical studies10.1179/016164105X25225 ↗
32. Regeneration in the central nervous system10.1016/S0531-5565(02)00165-1 ↗
33. Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways10.1038/sj.cdd.4401662 ↗
34. Neurotrophins protect against cytosine arabinoside-induced apoptosis of immature rat cerebellar neurons10.1016/j.neuint.2004.07.001 ↗
35. Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide10.1038/sj.cdd.4400439 ↗
36. Local acute application of BDNF in the lesioned spinal cord anti-inflammatory and anti-oxidant effects10.1097/00001756-200405190-00016 ↗
37. Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis10.1016/j.jns.2008.02.011 ↗
38. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex10.1016/S0306-4522(99)00296-1 ↗
39. Brain transplantation of immortalized human neural stem cells promotes functional recovery in mouse intracerebral hemorrhage stroke model10.1634/stemcells.2006-0409 ↗
40. Wound healing—aiming for perfect skin regeneration10.1126/science.276.5309.75 ↗
41. Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells10.1074/jbc.271.46.29461 ↗
42. Inhibition of endothelial cell proliferation by the recombinant kringle domain of tissue-type plasminogen activator10.1016/S0006-291X(03)00656-9 ↗
43. In vivo effect of brain-derived neurotrophic factor on the survival of developing dorsal root ganglion cells10.1002/j.1460-2075.1987.tb02589.x ↗
44. Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats
45. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats
46. Spontaneous intracerebral hemorrhage in humans: hematoma enlargement, clot lysis, and brain edema10.1007/3-211-30714-1_19 ↗