journal article·2002-01

Biomaterial patches sutured onto the rat stomach induce a set of genes encoding pancreatic enzymes

Marian Löbler, Marko Saß, Carmen Kunze, Klaus-Peter Schmitz, Ulrich T. Hopt

Biomaterials· Volume 23· Issue 2
Publisher page

Abstract

Asymmetric patches of polyhydroxybutyric acid with one smooth and one rough surface were produced by a dipping procedure. These patches were implanted into the rat gastrointestine and tissue samples were generated at distinct time intervals after surgery. The host's response towards the foreign material was analyzed by Differential Display and RNA profiles were compared to each other. One to two weeks after surgery a group of mRNAs encoding pancreatic enzymes was transiently present after biomaterial implantation.
Source: europepmc · Quality: candidate unverified · Source record ↗

Research context

OpenAlex topics: Tissue Engineering and Regenerative Medicine · Electrospun Nanofibers in Biomedical Applications · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (23)

Show source-provided references
1. Evaluation of human collagen biomaterials in the healing of colonic anastomoses in dogs
2. Prevention of arachnoiditis and postoperative tethering of the spinal cord with Gore-Tex surgical membrane10.1097/00006123-199804000-00076 ↗
3. Experimental evaluation of a new composite mesh with the selective property of incorporation to the abdominal wall without adhering to the intestines10.1002/jbm.820280312 ↗
4. Regeneration of pericardial tissue on absorbable polymer patches implanted into the pericardial sac. An immunohistochemical, ultrastructural and biochemical study in the sheep10.3109/14017439209099048 ↗
5. A new biodegradable patch for closure of atrial septal defect. An experimental study10.3109/14017439209099047 ↗
6. A biodegradable patch used as a pericardial substitute after cardiac surgery10.1055/s-2007-1013226 ↗
7. Pericardial substitution after cardiopulmonary bypass surgery10.1055/s-2007-1010194 ↗
8. A new resorbable wrap-around implant as an alternative nerve repair technique10.1054/jhsb.1998.0001 ↗
9. Neuronal survival using a resorbable synthetic conduit as an alternative to primary nerve repair10.1002/(SICI)1098-2752(1999)19:6<259::AID-MICR1>3.0.CO;2-Q ↗
10. Protection of intestinal anastomoses by biodegradable intraluminal bypass tubes under the condition of general peritonitis10.1007/BF02051171 ↗
11. Inflammatory response to implants10.1097/00002480-198804000-00005 ↗
12. Soft-tissue response to synthetic biomaterials10.1016/S0030-6665(20)30723-4 ↗
13. Evaluation of biological responses to polymeric biomaterials by RT-PCR analysis. I. Study of IL-1 beta mRNA expression10.1016/0142-9612(96)88675-3 ↗
14. Abundance, diversity, and regulation of mRNA sequence sets in soybean embryogenesis10.1016/0012-1606(81)90467-X ↗
15. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction10.1126/science.1354393 ↗
16. Distribution and cloning of eukaryotic mRNAs by means of differential display10.1093/nar/21.14.3269 ↗
17. Gapped BLAST and PSI-BLAST10.1093/nar/25.17.3389 ↗
18. A novel multispecific competitor fragment for quantitative PCR analysis of cytokine gene expression in rats10.1016/0022-1759(94)90139-2 ↗
19. Water transport properties in poly(3-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) biopolymers10.1002/(SICI)1097-4628(19990725)73:4<455::AID-APP1>3.0.CO;2-Y ↗
20. Cytokines and biocompatibility10.1159/000169968 ↗
21. Identifying differences in mRNA expression by representational difference analysis of cDNA10.1093/nar/22.25.5640 ↗
22. Freier T, Kunze C, Nischan C, Kramer S, Sternberg K, Saß M, Hopt UT, Behrend D, Schmitz K-P. In vitro and in vivo degradation studies for development of a new biodegradable one-sided porous patch based on poly-3-hydroxybutyrate, submitted.
23. Determination of the active sites serine of the poly(3-hydroxybutyrate) depolymerases of Pseudomonas lemoignei (PhaZ5) and of Alcaligenes faecalis10.1111/j.1574-6968.1996.tb08370.x ↗