Complex human model systems: from development through translation in pharma
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Abstract
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Research context
OpenAlex topics: Animal testing and alternatives · Pharmacogenetics and Drug Metabolism · Computational Drug Discovery Methods
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References (22)
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1. Organoid models: the future companions of personalized drug development10.1088/1758-5090/ad3e30 ↗
2. Complex in vitro models positioned for impact to drug testing in pharma: a review10.1088/1758-5090/ad6933 ↗
3. The use of microphysiological systems to model metastatic cancer10.1088/1758-5090/ad3b70 ↗
4. Incorporating biomechanics as a key evaluation metric for organoids10.1088/1758-5090/adb802 ↗
5. Endothelial extracellular vesicles enhance vascular self-assembly in engineered human cardiac tissues10.1088/1758-5090/ad76d9 ↗
6. A microvascularized in vitro liver model for disease modeling and drug discovery10.1088/1758-5090/ad818a ↗
7. A perfusable, vascularized kidney organoid-on-chip model10.1088/1758-5090/ad5ac0 ↗
8. A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction10.1088/1758-5090/ad17d0 ↗
9. A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin10.1088/1758-5090/ad5d1a ↗
10. Skin-on-a-chip technologies towards clinical translation and commercialization10.1088/1758-5090/ad5f55 ↗
11. Biomimetic human skin model patterned with rete ridges10.1088/1758-5090/acfc29 ↗
12. High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells10.1088/1758-5090/aced23 ↗
13. Development of a novel bioartificial cornea using 3D bioprinting based on electrospun micro-nanofibrous decellularized extracellular matrix10.1088/1758-5090/ad35ea ↗
14. A 3D-printed tumor-on-chip: user-friendly platform for the culture of breast cancer spheroids and the evaluation of anti-cancer drugs10.1088/1758-5090/ad5765 ↗
15. Cancer-mediated axonal guidance of sensory neurons in a microelectrode-based innervation MPS10.1088/1758-5090/ad218a ↗
16. A microphysiological assay for studying T-cell chemotaxis, trafficking and tumor killing10.1088/1758-5090/ad847f ↗
17. Acetylcholine-loaded nanoparticles protect against doxorubicin-induced toxicity in in vitro cardiac spheroids10.1088/1758-5090/adb7c2 ↗
18. Dynamic culture of cerebral organoids using a pillar/perfusion plate for the assessment of developmental neurotoxicity10.1088/1758-5090/ad867e ↗
19. Basic models to advanced systems: harnessing the power of organoids-based microphysiological models of the human brain10.1088/1758-5090/ad4c08 ↗
20. An immunocompetent human kidney on-a-chip model to study renal inflammation and immune-mediated injury10.1088/1758-5090/ad9fdf ↗
21. Advancing preclinical drug evaluation through automated 3D imaging for high-throughput screening with kidney organoids10.1088/1758-5090/ad38df ↗
22. Robust and customizable spheroid culture system for regenerative medicine10.1088/1758-5090/ad6795 ↗