journal article·2025-07-01

Progress in the application of organoids for exploring the relationship between macrophages and various lung diseases

Jiawang Wu, Ting Liu, Xinting Zhang, Chongchang Qu, Juan Wu, Shuanglan Xu, Jiao Yang, Xiqian Xing

Biofabrication· Volume 17· Issue 3
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Abstract

Abstract Organoids cultured ex vivo mimic in vivo tissue and organ characteristics. They have become a focus in research for their potential in modeling macrophage function in respiratory diseases, offering insights into disease mechanisms and therapeutic strategies. A number of studies have confirmed organoids’ utility in dissecting microbial interactions, disease modeling, genetic manipulation, and high-throughput drug screening for efficacy and safety. This review summarizes the research progress on organoids in exploring macrophage involvement in pulmonary diseases.
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Research context

OpenAlex topics: Inhalation and Respiratory Drug Delivery · Neonatal Respiratory Health Research · Chronic Obstructive Pulmonary Disease (COPD) Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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