Non-invasive, non-enzymatic, non-serodiagnostic, and home-detecting paper-based “abnormal UA alarm” for early diagnosis of UA associated diseases
Source abstract
Abstract
Uric acid (UA) level is a pivotal clinical human-health biomarker providing predictive feedback for multitudinous well-known kidney, cardiovascular and metabolic syndrome diseases. Off-the-shelf UA detection methods clinically rely on uricase suffer from limitations such as high costs, longstanding result acquisition, circumscribed testing locations, rigorous expertise requirements, and difficulty in home-detecting due to serum testing systems. Here, inspired by the pH-paper, a scaleable, rapid, non-invasive/-enzymatic/-serodiagnostic, and home-detecting “abnormal UA alarm” platform for UA detection in saliva was developed by strategically integrating the proposed paper-based fluorescent sensing-materials (NIFP-SM) with a user-orientated intelligent red-green-blue (RGB) analysis device. Therefore, NIFP-SM is nano-engineered through straightforward interfacial interactions of functional building blocks of on-demand naphthyl imide-derived fluorescent self-assembled micro-particles (NIFS) with lamellar structure and commercially-used filter paper. The NIFS possesses dominantly wide detection range (0–5 000 µmol/L) and high sensitivity (limit of detection = 0.91 µmol/L). Surprisingly, NIFS exhibited outstanding identifiability for uric acid even in the presence of 16 interferents, substantiating accurate detection-capability in intricate environments. Thus NIFP-SM equipped with NIFS resoundingly achieved efficient, rapid, and on-site visual detection of UA in saliva, urine-simulants, and foods. Further, the NIFP-SM-based automatic analysis platform integrated with an intelligent RGB analysis device was manufactured and enabled accurate quantitative, low-cost, non-invasive/-enzymatic/-serodiagnostic, rapid, home-detecting for UA, eliminating the need for costly equipment and specialized personnel and thereby facilitating early-warning detection of abnormal UA-levels associated diseases.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Advanced Chemical Sensor Technologies · Respiratory viral infections research · Influenza Virus Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (53)
Show source-provided references
1. An enzyme-free fluorescent probe based on carbon dots–MnO2 nanosheets for determination of uric acid10.1016/j.jphotochem.2018.02.002 ↗
2. Correlation of salivary uric acid and cardiac autonomic modulation in metabolic syndrome population
3. Saliva for assessing creatinine, uric acid, and potassium in nephropathic patients10.1186/s12882-019-1437-4 ↗
4. Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle10.1373/clinchem.2008.105320 ↗
5. Developing activated carbon veil electrode for sensing salivary uric acid10.3390/bios11080287 ↗
6. Selective inhibition of β-N-acetylhexosaminidases by thioglycosyl–naphthalimide hybrid molecules10.1016/j.bmc.2017.11.042 ↗
7. Purine-rich foods, dairy and protein intake, and the risk of gout in men10.1056/NEJMoa035700 ↗
8. A pyrene-functionalized metal-organic framework for nonenzymatic and ratiometric detection of uric acid in biological fluid via conformational change10.1021/acs.inorgchem.8b03629 ↗
9. Validation and comparison of analytical methods for the determination of uric acid in pulses and cereals by salting out assisted extraction by rapid resolution liquid chromatography10.1016/j.jchromb.2021.122894 ↗
10. Construction and application of an amperometric uric acid biosensor based on covalent immobilization of uricase on iron oxide nanoparticles/chitosan-g-polyaniline composite film electrodeposited on Pt electrode10.1016/j.snb.2013.12.010 ↗
11. Nanomolar level detection of uric acid in blood serum and pest-infested grain samples by an amphiphilic probe10.1021/acs.analchem.7b02344 ↗
12. Determination of storage time of saliva samples obtained from patients with and without chronic periodontitis for the comparison of some biochemical and cytological parameters10.1002/jcla.21592 ↗
13. Digital quantification method for sensitive point-of-care detection of salivary uric acid using smartphone-assisted μPADs10.1021/acssensors.2c00854 ↗
14. Correlation of biochemical parameters in serum and saliva in chronic azotemic patients and patients on chronic hemodialysis
15. Influence of sampling conditions, salivary flow, and total protein content in uric acid measurements in saliva10.3390/antiox8090389 ↗
16. Saliva: a diagnostic window to the body, both in health and in disease
17. Determination of uric acid in human saliva by capillary electrophoresis with electrochemical detection: potential application in fast diagnosis of gout10.1007/s00216-004-2848-y ↗
18. Determination of uric acid and p-aminohippuric acid in human saliva and urine using capillary electrophoresis with electrochemical detection potential application in fast diagnosis of renal disease10.1016/j.jchromb.2005.03.049 ↗
19. Uric acid monitoring with a smartphone as the electrochemical analyzer10.1021/acs.analchem.6b04345 ↗
20. A europium-based MOF fluorescent probe for efficiently detecting malachite green and uric acid10.1021/acs.inorgchem.0c00620 ↗
21. Determination of uric acid in human saliva by high-performance liquid chromatography with amperometric electrochemical detection10.1016/S1570-0232(02)00850-4 ↗
22. Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics10.1016/j.bios.2015.07.039 ↗
23. Sensing of uric acid via cascade catalysis of uricase and a biomimetic catalyst10.1016/j.snb.2016.04.033 ↗
24. Simple method for simultaneous detection of uric acid, xanthine and hypoxanthine in fish samples using a glassy carbon electrode modified with as commercially received multiwalled carbon nanotubes10.1039/c1ay05065f ↗
25. Highly selective and safe ‘in vitro’ detection of biologically important ‘uric acid’ in living cells by a new fluorescent ‘turn-on’ probe along with quantum chemical calculation10.1016/j.snb.2018.02.170 ↗
26. Plasmonic array assisted mass spectrometry for preferential metabolite detection10.1016/j.cej.2024.150224 ↗
27. Phosphonate MOFs composite as off-on fluorescent sensor for detecting purine metabolite uric acid and diagnosing hyperuricuria10.1021/acs.inorgchem.6b03009 ↗
28. Rational design of mimic multienzyme systems in hierarchically porous biomimetic metal-organic frameworks10.1021/acsami.8b09388 ↗
29. Novel portable sensing system with integrated multifunctionality for accurate detection of salivary uric acid10.3390/bios11070242 ↗
30. Human metabolite detection by surface-enhanced Raman spectroscopy
31. Association between body mass index and salivary uric acid among Mexican-origin infants, youth and adults: gender and developmental differences10.1002/dev.21492 ↗
32. Understanding electroanalytical measurements in authentic human saliva leading to the detection of salivary uric acid10.1016/j.snb.2018.02.014 ↗
33. Rapid method for the quantification of reduced and oxidized glutathione in human plasma and saliva10.1021/acs.analchem.6b04186 ↗
34. The copper(Ⅱ)-catalyzed oxidation of glutathione10.1002/chem.201603366 ↗
35. Detection of insect infestations in cereals by measurement of uric acid
36. The validity, stability, and utility of measuring uric acid in saliva10.2217/bmm-2017-0336 ↗
37. Pyrene appended thymine derivative for selective turn-on fluorescence sensing of uric acid in live cells10.1039/C6RA15980J ↗
38. Selectivity enhancement for uric acid detection via in situ preparation of blue emissive carbon dots entrapped in chromium metal-organic frameworks10.1021/acsomega.2c00790 ↗
39. 2-Hexylaminoethylamidonaphthalimide as Cu2+ sensor10.1016/j.saa.2014.02.120 ↗
40. Uric acid concentration in saliva and its changes with the patients receiving treatment for hyperuricemia10.1007/s11306-011-0334-z ↗
41. Printed combinatorial sensors for simultaneous detection of ascorbic acid, uric acid, dopamine, and nitrite10.1021/acsomega.7b00681 ↗
42. Chromatographic method for the determination of inflammatory biomarkers and uric acid in human saliva10.1016/j.talanta.2021.122598 ↗
43. Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders10.1515/cclm-2020-1533 ↗
44. The enzyme free uric acid sensor based on iron doped CuO nanostructures for the determination of uric acid from commercial seafood10.1007/s11664-020-08345-x ↗
45. Absolute quantification of uric acid in human urine using surface enhanced Raman scattering with the standard addition method10.1021/acs.analchem.6b04588 ↗
46. Aggregation-induced emission: challenges and opportunities10.1093/nsr/nwaa222 ↗
47. Photoluminescence of Tilapia skin collagen: aggregation-induced emission with clustering triggered emission mechanism and its multiple applications10.1016/j.ijbiomac.2021.05.063 ↗
48. Fluorescence turn-on detection of uric acid by a water-stable metal–organic nanotube with high selectivity and sensitivity10.1039/C6TC05034D ↗
49. Nanomaterial-based electrochemical nanodiagnostics for human and gut metabolites diagnostics: recent advances and challenges10.3390/bios12090733 ↗
50. Organic luminescent materials: the concentration on aggregates from aggregation-induced emission10.1002/agt2.2 ↗
51. Salivary uric acid as a noninvasive biomarker for monitoring the efficacy of urate-lowering therapy in a patient with chronic gouty arthropathy10.1016/j.cca.2015.08.005 ↗
52. An enzyme-free fluorescent sensing platform for the detection of uric acid in human urine10.1016/j.jlumin.2021.118076 ↗
53. An eco-friendly hydrophilic interaction HPLC method for the determination of renal function biomarkers, creatinine and uric acid, in human fluids10.1039/c2ay26362a ↗