Recent advancements in applications of chitosan-based biomaterials for skin tissue engineering
Source abstract
Abstract
The use of polymer based composites in the treatment of skin tissue damages, has got huge attention in clinical demand, which enforced the scientists to improve the methods of biopolymer designing in order to obtain highly efficient system for complete restoration of damaged tissue. In last few decades, chitosan-based biomaterials have major applications in skin tissue engineering due to its biocompatible, hemostatic, antimicrobial and biodegradable capabilities. This article overviewed the promising biological properties of chitosan and further discussed the various preparation methods involved in chitosan-based biomaterials. In addition, this review also gave a comprehensive discussion of different forms of chitosan-based biomaterials including membrane, sponge, nanofiber and hydrogel that were extensively employed in skin tissue engineering. This review will help to form a base for the advanced applications of chitosan-based biomaterials in treatment of skin tissue damages.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Nanocomposite Films for Food Packaging · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
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1. Chitin and chitosan from Brazilian Atlantic Coast: isolation, characterization and antibacterial activity10.1016/j.ijbiomac.2015.06.027 ↗
2. Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management10.1016/j.ijbiomac.2019.06.022 ↗
3. Wound dressing based on electrospun PVA/chitosan/starch nanofibrous mats: fabrication, antibacterial and cytocompatibility evaluation and in vitro healing assay10.1016/j.ijbiomac.2018.10.115 ↗
4. Chitosan based hydrogels: characteristics and pharmaceutical applications
5. Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery10.2147/DDDT.S99651 ↗
6. The fabrication of elastin-based hydrogels using high pressure CO210.1016/j.biomaterials.2008.09.031 ↗
7. Evaluation of chitosan nano dressing for wound healing: characterization, in vitro and in vivo studies10.1016/j.ijbiomac.2013.03.002 ↗
8. Chitosan membrane as a wound-healing dressing: characterization and clinical application10.1002/jbm.b.30000 ↗
9. Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model
10. Strategies to improve chitosan hemocompatibility: a review10.1016/j.eurpolymj.2014.01.033 ↗
11. Antibacterial/antifungal activity of extracted chitosan from American cockroach (Dictyoptera: Blattidae) and German cockroach (Blattodea: Blattellidae)10.1093/jme/tjz082 ↗
12. Chitosan/TiO2 composite membrane improves proliferation and survival of L929 fibroblast cells: application in wound dressing and skin regeneration10.1016/j.ijbiomac.2017.02.017 ↗
13. Combining xanthan and chitosan membranes to multipotent mesenchymal stromal cells as bioactive dressings for dermo-epidermal wounds10.1177/0885328214553959 ↗
14. Cowpea resistance induced against Fusarium oxysporum f. sp. tracheiphilum by crustaceous chitosan and by biomass and chitosan obtained from Cunninghamella elegans10.1016/j.biocontrol.2015.09.006 ↗
15. Simple chemical transformation of lignocellulosic biomass into furans for fuels and chemicals10.1021/ja808537j ↗
16. Cell infiltration and growth in a low density, uncompressed three-dimensional electrospun nanofibrous scaffold10.1016/j.biomaterials.2010.10.056 ↗
17. Chitin-chitosan yield of freshwater crab (Potamon potamios, Olivier 1804) shell
18. Tissue engineering of skin and regenerative medicine for wound care10.1186/s41038-017-0103-y ↗
19. Sorbitol-plasticized and neutralized chitosan membranes as skin substitutes10.1590/1516-1439.025015 ↗
20. Chitosan hydrogels containing nanoencapsulated phenytoin for cutaneous use: skin permeation/penetration and efficacy in wound healing10.1016/j.msec.2018.11.013 ↗
21. pH effects on solubility, Zeta potential, and correlation between antibacterial activity and molecular weight of chitosan10.1016/j.carbpol.2015.07.072 ↗
22. Effects of chitosan molecular weight on its antioxidant and antimutagenic properties10.1016/j.carbpol.2017.11.047 ↗
23. 2, 5-Furandicarboxylic acid production via catalytic oxidation of 5-hydroxymethylfurfural: catalysts, processes and reaction mechanism10.1016/j.jechem.2020.05.068 ↗
24. Electrospun chitosan-graft-poly (ɛ-caprolactone)/poly (ɛ-caprolactone) cationic nanofibrous mats as potential scaffolds for skin tissue engineering10.1016/j.ijbiomac.2010.09.019 ↗
25. Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment10.1016/j.carbpol.2018.10.068 ↗
26. Chitosan: an update on potential biomedical and pharmaceutical applications10.3390/md13085156 ↗
27. Quality assessment of low molecular weight chitosan coating on sliced red pitayas10.1016/j.jfoodeng.2006.02.047 ↗
28. Anti-inflammatory effects of low-molecular weight chitosan oligosaccharides in IgE–antigen complex-stimulated RBL-2H3 cells and asthma model mice10.1016/j.intimp.2011.12.027 ↗
29. Microwave-assisted hydrogel synthesis: a new method for crosslinking polymers in aqueous solutions10.1002/marc.201100742 ↗
30. Chitosan: a versatile semi-synthetic polymer in biomedical applications10.1016/j.progpolymsci.2011.02.001 ↗
31. Introduction to tissue engineering and application for cartilage engineering
32. Evaluation of hemagglutination activity of chitosan nanoparticles using human erythrocytes
33. Antimicrobial effect of chitosan nanoparticles on Streptococcus mutans biofilms10.1128/AEM.02941-10 ↗
34. Preparation and characterization of chitosan obtained from shells of shrimp (Litopenaeus vannamei Boone)10.3390/md15050141 ↗
35. Differential healing of full thickness rabbit skin wound by fibroblast loaded chitosan sponge10.1166/jbt.2013.1094 ↗
36. Fabrication and characterization of chitosan-gelatin blend nanofibers for skin tissue engineering10.1002/jbm.b.31651 ↗
37. Green synthesis approach: extraction of chitosan from fungus mycelia10.3109/07388551.2012.717217 ↗
38. Chitin and chitosan from Basidiomycetes10.1016/j.ijbiomac.2007.10.005 ↗
39. Chitosan-based hydrogels: preparation, properties, and applications
40. Biocompatibility of chitosan/heparin multilayer coating on NiTi alloy10.4028/www.scientific.net/MSF.610-613.1179 ↗
41. Preparation of water-soluble chitosan from shrimp shell and its antibacterial activity10.1016/j.ifset.2008.07.004 ↗
42. Electrospinning of chitosan solutions in acetic acid with poly(ethylene oxide)10.1163/156856204774196171 ↗
43. A nanofibrous composite membrane of PLGA-chitosan/PVA prepared by electrospinning10.1016/j.eurpolymj.2006.04.021 ↗
44. 3D network of cellulose-based energy storage devices and related emerging applications10.1039/C6MH00500D ↗
45. Chitosan/alginate hydrogels containing Alpha-tocopherol for wound healing in rat model10.1016/j.jddst.2019.02.032 ↗
46. Antibacterial activity of chitosan chemically modified with new technique
47. Anti-inflammatory activity of chitooligosaccharides in vivo10.3390/md8061763 ↗
48. The chitosan hydrogels: from structure to function10.1039/C8NJ03482F ↗
49. Thermo-compression molding of chitosan with a deep eutectic mixture for biofilms development10.1039/C5GC02231B ↗
50. Preparation of chitosan scaffolds for tissue engineering using freeze drying technology
51. Scaffold: a novel carrier for cell and drug delivery10.1615/CritRevTherDrugCarrierSyst.v29.i1.10 ↗
52. Structural and surface compatibility study of modified electrospun poly(ε-caprolactone) (PCL) composites for skin tissue engineering10.1208/s12249-016-0500-8 ↗
53. Evaluation of the antimicrobial activity of chitosan and its quaternized derivative on E. coli and S. aureus growth10.1016/j.bjp.2015.09.010 ↗
54. Characterization and in vitro evaluation of cytotoxicity, antimicrobial and antioxidant activities of chitosans extracted from three different marine sources10.1007/s12010-015-1724-x ↗
55. Chitosan: a promising marine polysaccharide for biomedical research10.4103/0973-7847.176545 ↗
56. Preparation, characteristics and assessment of a novel gelatin-chitosan sponge scaffold as skin tissue engineering material10.1016/j.ijpharm.2014.09.036 ↗
57. Microwave-assisted synthesis of chitosan/polyvinyl alcohol silver nanoparticles gel for wound dressing applications10.1155/2016/1584046 ↗
58. Electrospinning and electrically forced jets. II10.1063/1.1384013 ↗
59. Screening of fungi for chitosan producers, and copper adsorption capacity of fungal chitosan and chitosanaceous materials10.1016/j.carbpol.2004.06.015 ↗
60. Fabrication and characteristics of chitosan sponge as a tissue engineering scaffold10.1155/2014/786892 ↗
61. Antifungal activity of chitosan nanoparticles and correlation with their physical properties10.1155/2012/632698 ↗
62. In vitro antibacterial activity of shrimp chitosan against Salmonela paratyphi and Staphylococcus aureus10.3329/jbcs.v24i2.9707 ↗
63. Biomaterials based on chitin and chitosan in wound dressing applications10.1016/j.biotechadv.2011.01.005 ↗
64. Fabrication of porous chitosan scaffolds for soft tissue engineering using dense gas CO210.1016/j.actbio.2010.11.043 ↗
65. The immunological anatomy of the skin10.1038/s41577-018-0084-5 ↗
66. Physicochemical properties of chitin and chitosan produced from medicinal fungus (Fomitopsis pinicola)10.1007/s11483-014-9378-8 ↗
67. Comparison of antimicrobial activities of newly obtained low molecular weight scorpion chitosan and medium molecular weight commercial chitosan10.1016/j.jbiosc.2015.11.005 ↗
68. Extraction and characterization of chitin and chitosan with antimicrobial and antioxidant activities from cosmopolitan Orthoptera species (Insecta)10.1007/s12257-014-0391-z ↗
69. Physicochemical comparison of chitin and chitosan obtained from larvae and adult Colorado potato beetle (Leptinotarsa decemlineata)10.1016/j.msec.2014.09.004 ↗
70. Physicochemical characterization of chitin and chitosan obtained from resting eggs of Ceriodaphnia quadrangula (Branchiopoda: cladocera: daphniidae)10.1163/1937240X-00002221 ↗
71. New chitin, chitosan, and O-carboxymethyl chitosan sources from resting eggs of Daphnia longispina (Crustacea); with physicochemical characterization, and antimicrobial and antioxidant activities10.1007/s12257-013-0488-9 ↗
72. A physicochemical characterization of fully acetylated chitin structure isolated from two spider species: with new surface morphology10.1016/j.ijbiomac.2014.02.010 ↗
73. Polysaccharide composites as a wound-healing sponge
74. Competitive biological activities of chitosan and its derivatives: antimicrobial, antioxidant, anticancer, and anti-inflammatory activities
75. Production and characterization of chitosan obtained from Rhizopus oryzae grown on potato chip processing waste10.1007/s11274-010-0561-x ↗
76. Antimicrobial properties of chitosan and mode of action: a state of the art review10.1016/j.ijfoodmicro.2010.09.012 ↗
77. One-pot reactive electrospinning of chitosan/PVA hydrogel nanofibers reinforced by halloysite nanotubes with enhanced fibroblast cell attachment for skin tissue regeneration10.1016/j.colsurfb.2019.03.054 ↗
78. Kronenthal · 2013
79. Metal–organic framework (MOF)-derived effective solid catalysts for valorization of lignocellulosic biomass10.1021/acssuschemeng.8b03683 ↗
80. Extraction and characterization of chitin and chitosan from crustacean by-products: biological and physicochemical properties
81. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing10.1039/C7RA13510F ↗
82. Curcumin-releasing chitosan/aloe membrane for skin regeneration10.1016/j.cej.2018.11.073 ↗
83. Biomimetic materials for tissue engineering10.1016/j.addr.2007.08.041 ↗
84. Chitosan membrane dressings toughened by glycerol to load antibacterial drugs for wound healing10.1016/j.msec.2017.08.052 ↗
85. Chitosan microparticles exert broad-spectrum antimicrobial activity against antibiotic-resistant micro-organisms without increasing resistance10.1021/acsami.6b00894 ↗
86. Fabrication and characterization of chitosan-vitamin C-lactic acid composite membrane for potential skin tissue engineering10.1155/2019/4362395 ↗
87. Silver nanoparticle impregnated chitosan-PEG hydrogel enhances wound healing in diabetes induced rabbits10.1016/j.ijpharm.2019.01.019 ↗
88. Ibuprofen loaded PVA/chitosan membranes: a highly efficient strategy towards an improved skin wound healing10.1016/j.carbpol.2016.12.029 ↗
89. Chitosan oligosaccharide (COS): an overview10.1016/j.ijbiomac.2019.01.192 ↗
90. Curcumin-loaded chitosan/gelatin composite sponge for wound healing application10.1155/2013/106570 ↗
91. Stability and antibacterial activity of chitosan solutions affected by storage temperature and time10.1016/j.carbpol.2005.12.036 ↗
92. Antibacterial activity of chitosans and chitosan oligomers with different molecular weights10.1016/S0168-1605(01)00717-6 ↗
93. Characterisation of chitosan from blowfly larvae and some crustacean species from Kenyan Marin waters prepared under different conditions10.4314/wiojms.v4i1.28478 ↗
94. Chitosan drives anti-inflammatory macrophage polarisation and pro-inflammatory dendritic cell stimulation10.22203/eCM.v024a10 ↗
95. Effectiveness of chitosan scaffold in skin, bone and cartilage healing10.1016/j.ijbiomac.2017.06.124 ↗
96. Chitosan: application in tissue engineering and skin grafting10.1007/s10965-017-1286-4 ↗
97. Park · 2012 · 47
98. Fluorinated methacrylamide chitosan hydrogel dressings improve regenerated wound tissue quality in diabetic wound healing10.1089/wound.2018.0887 ↗
99. Traditional therapies for skin wound healing10.1089/wound.2013.0506 ↗
100. Cell-loaded gelatin/chitosan scaffolds fabricated by salt-leaching/lyophilization for skin tissue engineering: in vitro and in vivo study10.1002/jbm.a.35054 ↗