Do Uncommon Plant Phenolic Compounds Have Uncommon Properties? A Mini Review on Novel Flavonoids
Source abstract
Abstract
Unique plants and their properties, once considered synonymous to medicine, remain a potent source for new compounds in modern science. Plant polyphenols and natural products continue to be investigated for effective treatments for the most persistent of human ailments. In this review, fifty novel plant phenolic compounds have been compiled and briefly described from the previous five years. Select compounds and notable plant species from genus Morinda and Sophora are further expanded on. Traditional medicine plants often contain rich and diverse mixtures of flavonoids, from which rare compounds should receive attention. The bioactivity of crude plant extracts, purified compounds and mixtures can differ greatly, requiring that these interactions and mechanisms of action be investigated in greater detail. Novel applications of uncommon natural products, namely mimosine and juglone, are explored within this review. The 2019 coronavirus pandemic has resulted in abrupt spike of related scientific publications: speculation is made regarding plant natural products and future of antiviral drug discovery.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Morinda citrifolia extract uses · Pharmacological Effects of Natural Compounds · Bioactive Compounds and Antitumor Agents
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
Show source-provided references
1. Antiproliferative activity of stilbene derivatives and other constituents from the stem bark of Morus nigra L10.1080/14786419.2019.1573236 ↗
2. Prenylated flavonoids from the roots and rhizomes of Sophora tonkinensis and their effects on the expression of inflammatory mediators and proprotein convertase subtilisin/kexin type 910.1021/acs.jnatprod.8b00748 ↗
3. Total synthesis, cytotoxic effects of damnacanthal, nordamnacanthal and related anthraquinone analogues
4. Curviflorside and curviflorin, new naphthalene glycoside and flavanol from Plicosepalus curviflorus10.1515/znc-2016-0180 ↗
5. The pharmacology of the genus Sophora (Fabaceae): an updated review10.1016/j.phymed.2019.153070 ↗
6. Three new flavonoids, proanthocyanidin, and accompanying phenolic constituents from Feijoa sellowiana10.1080/09168451.2017.1412246 ↗
7. Combinatorial cytotoxic effects of damnacanthal and doxorubicin against human breast cancer MCF-7 cells in vitro10.3390/molecules21091228 ↗
8. Giant Leucaena (Leucaena leucocephala subsp. glabrata): a versatile tree-legume for sustainable agroforestry10.1007/s10457-019-00392-6 ↗
9. Novel acylated flavonol tetraglycoside with inhibitory effect on lipid accumulation in 3T3-L1 cells from Lu'an GuaPian tea and quantification of flavonoid glycosides in six major processing types of tea10.1021/acs.jafc.7b00239 ↗
10. A concise review of current lignin production, applications, products and their environmental impact10.1016/j.indcrop.2019.111526 ↗
11. A synthetic derivative of houttuynoid B prevents cell entry of Zika virus10.1016/j.antiviral.2019.104644 ↗
12. Absolute configuration and anti-cancer effect of prenylated flavonoids and flavonostilbenes from Sophora pachycarpa: possible involvement of Wnt signaling pathway10.1016/j.bioorg.2019.01.051 ↗
13. Identification of a flavonoid isolated from plum (Prunus domestica) as a potent inhibitor of Hepatitis C virus entry10.1038/s41598-017-04358-5 ↗
14. Two new phenolic constituents from the root bark of Morus alba L. and their cardioprotective activity10.1080/14786419.2017.1309535 ↗
15. Unique flavanol-anthocyanin condensed forms in Apache red purple corn10.1021/acs.jafc.8b04723 ↗
16. A novel flavonoid kushenol Z from Sophora flavescens mediates mTOR pathway by inhibiting phosphodiesterase and Akt activity to induce apoptosis in non-small-cell lung cancer cells10.3390/molecules24244425 ↗
17. Synergistic activity of baicalein with ribavirin against influenza A (H1N1) virus infections in cell culture and in mice10.1016/j.antiviral.2011.07.008 ↗
18. Synthesis and antibacterial and antiviral activities of myricetin derivatives containing a 1, 2, 4-triazole Schiff base10.1039/C9RA05139B ↗
19. Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection10.1016/j.apjtm.2015.12.002 ↗
20. Simultaneous detection of pro- and antioxidative effects in the variants of the deoxyribose degradation assay10.1021/jf902395k ↗
21. Exploration of pro-oxidant and antioxidant activities of the flavonoid myricetin10.1179/1351000211Y.0000000015 ↗
22. Pro- and antioxidant activity of three selected flavan type flavonoids: catechin, eriodictyol and taxifolin10.3390/ijms17121986 ↗
23. Morindaquinone, a new bianthraquinone from Morinda coreia roots
24. Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus10.1016/S0140-6736(03)13615-X ↗
25. Mimosine inhibits viral DNA synthesis through ribonucleotide reductase10.1006/viro.1994.1636 ↗
26. Dang · 2013 · 299
27. Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-Resistant Staphylococcus spp10.1016/j.micpath.2019.01.030 ↗
28. In silico and in vitro neutralization of PLA2 activity of Daboxin P by butein, mimosine and bakuchiol10.1016/j.ijbiomac.2020.09.223 ↗
29. Modulation of nitric oxide by flavonoids10.1039/C4FO00144C ↗
30. Biosynthesis of the 2-pyridone tenellin in the insect pathogenic fungus Beauveria bassiana10.1002/cbic.200600398 ↗
31. Chemical and biological characterisation of sapinopyridione, a phytotoxic 3, 3, 6-trisubstituted-2, 4-pyridione produced by Sphaeropsis sapinea, a toxigenic pathogen of native and exotic conifers, and its derivatives10.1016/j.phytochem.2006.03.017 ↗
32. Phenolic constituents from Rheum nobile and their antioxidant activity10.1080/14786419.2017.1303691 ↗
33. Novel juglone and plumbagin 5-O derivatives and their in vitro growth inhibitory activity against apoptosis-resistant cancer cells10.1016/j.bmcl.2015.12.017 ↗
34. Chemical constituents of the antiulcer purified fractions of Lindera reflexa Hemsl. and its quantitative analysis10.1016/j.fitote.2020.104795 ↗
35. Two new prenylflavonoids from Morus alba10.1080/10286020.2017.1343303 ↗
36. The noni anthraquinone damnacanthal is a multi-kinase inhibitor with potent anti-angiogenic effects10.1016/j.canlet.2016.10.037 ↗
37. Mimosine arrests DNA synthesis at replication forks by inhibiting deoxyribonucleotide metabolism10.1074/jbc.270.16.9597 ↗
38. Medicinal plants from Peru: a review of plants as potential agents against cancer10.2174/187152006778226486 ↗
39. Influence of ferric chloride treated Leucaena leucocephala on metabolism of mimosine and 3-hydroxy 4(1H)-pyridone in growing rabbits10.1016/S0377-8401(98)00172-2 ↗
40. Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir10.1016/j.phymed.2009.06.002 ↗
41. Cajanusflavanols A-C, three pairs of flavonostilbene enantiomers from Cajanus cajan10.1021/acs.orglett.8b00010 ↗
42. Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells
43. Α-Glucosidase inhibitory, antibacterial, and antioxidant activities of natural substances from the wood of Derris reticulata Craib
44. New flavonoid glycosides from two Astragalus species (Fabaceae) and validation of their antihyperglycaemic activity using molecular modelling and in vitro studies10.1016/j.indcrop.2018.03.034 ↗
45. Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism10.1016/j.fitote.2018.05.016 ↗
46. Α-Glucosidase inhibition by prenylated and lavandulyl compounds from Sophora flavescens roots and in silico analysis10.1016/j.ijbiomac.2017.04.092 ↗
47. A novel anthraquinone from Morinda lucida Benth (Rubiaceae)
48. A review on phytochemical, ethnomedical and pharmacological studies on genus Sophora10.1590/S0102-695X2012005000043 ↗
49. Metal self-assembly mimosine peptides with enhanced antimicrobial activity: towards a new generation of multitasking chelating agents10.1039/C9DT04545G ↗
50. Anticancer potential of damnacanthal and nordamnacanthal from Morinda elliptica roots on T-lymphoblastic leukemia cells10.3390/molecules26061554 ↗
51. Immunomodulatory and anti-SARS activities of Houttuynia cordata10.1016/j.jep.2008.03.018 ↗
52. Genistein has antiviral activity against Herpes B virus and acts synergistically with antiviral treatments to reduce effective dose10.3390/v11060499 ↗
53. Astrernestin, a novel aurone-phenylpropanoid adduct from the roots of Astragalus ernestii10.1080/14786419.2019.1596101 ↗
54. Evaluation of the immunity activity of glycyrrhizin in AR mice
55. Anti-inflammatory and antiproliferative prenylated isoflavone derivatives from the fruits of Ficus carica10.1021/acs.jafc.9b00865 ↗
56. Chemical constituents of Sophora flavescens Ait. and cytotoxic activities of two new compounds
57. New anthraquinone derivatives from the stem barks of Morinda lucida Benth10.1016/j.phytol.2020.06.010 ↗
58. Anti-inflammatory naphthoates and anthraquinones from the roots of Morinda officinalis10.1016/j.bioorg.2021.104800 ↗
59. (±) Erysectin A, a new isoprenylated isoflavone with a rare acetonyl group from Erythrina secundiflora Hassk
60. A new anthraquinone and a new naphthoquinone from the whole plant of Spermacoce latifolia10.1080/10286020.2017.1279609 ↗
61. New flavonoids from the roots of Sophora davidii (Franch.) Skeels and their glucose transporter 4 translocation activities10.1016/j.bioorg.2020.104500 ↗
62. Anti-bacterial activity of phenolic compounds against Streptococcus pyogenes10.3390/medicines4020025 ↗
63. New flavonoid and stilbene derivatives from the fruits of Macaranga balansae10.1080/14786419.2019.1587425 ↗
64. Isolation and characterization of antisalmonellal anthraquinones and coumarins from Morinda lucida Benth. (Rubiaceae)10.1007/s11696-020-01460-3 ↗
65. Sephadex® LH-20, isolation, and purification of flavonoids from plant species: a comprehensive review10.3390/molecules25184146 ↗
66. Antiviral activity of Faramea bahiensis leaves on dengue virus type-2 and characterization of a new antiviral flavanone glycoside10.1016/j.phytol.2017.01.013 ↗
67. Mimosine dipeptide enantiomsers: improved inhibitors against melanogenesis and cyclooxygenase
68. Neuraminidase inhibitors from the roots of Caragana sinica10.1002/cbdv.202000470 ↗
69. A stilbene dimer and flavonoids from the aerial parts of Chromolaena odorata with proprotein convertase subtilisin/kexin type 9 expression inhibitory activity10.1016/j.bioorg.2020.103869 ↗
70. New isoflavanes from Spatholobus suberectus and their cytotoxicity against human breast cancer cell lines10.3390/molecules24183218 ↗
71. Search for antimicrobial activity among fifty-two natural and synthetic compounds identifies anthraquinone and polyacetylene classes that inhibit Mycobacterium tuberculosis10.3389/fmicb.2020.622629 ↗
72. A new dimethoxy dihydrochalcone isolated from the shoots of Empetrum nigrum L
73. Antifungal activity of compounds from the stems of Dalbergia stipulacea against Pythium insidiosum
74. Potent in vitro antiviral activity of Cistus incanus extract against HIV and Filoviruses targets viral envelope proteins10.1038/srep20394 ↗
75. A phenol-enriched cuticle is ancestral to lignin evolution in land plants10.1038/ncomms14713 ↗
76. Synthesis, antibacterial and antifungal activities of naphthoquinone derivatives: a structure-activity relationship study10.1007/s00044-016-1550-x ↗
77. Two novel coumarins bearing an acetophenone derivative from the leaves of Melicope Quercifolia10.1080/14786419.2019.1644634 ↗
78. Decomposition of fruit rot toxin A, a host-selective phytotoxin from Botryosphaeria berengeriana
79. An antiviral mechanism of nitric oxide: inhibition of a viral protease10.1016/S1074-7613(00)80003-5 ↗
80. New flavanol dimers from the bark of Celtis tetrandra and their TRAIL resistance-overcoming activity
81. Effects of damnacanthal and nordamnacanthal on proliferation, apoptosis, and migration of oral squamous cell carcinoma cells. Asian Pac
82. Anticancer effects of extracts from the fruit of Morinda citrifolia (noni) in breast cancer cell lines
83. Indian Morinda species: a review10.1002/ptr.6579 ↗
84. Antibacterial activity in solvent extract of different parts of Morinda citrifolia plant
85. Advances on antiviral activity of Morus spp. plant extracts: human coronavirus and virus-related respiratory tract infections in the spotlight10.3390/molecules25081876 ↗
86. Cytotoxic and anti-HIV-1 activities of triterpenoids and flavonoids isolated from leaves and twigs of Gardenia sessiliflora10.1016/j.phytol.2019.10.007 ↗
87. Dual purpose secondary compounds: phytotoxin of Centaurea diffusa also facilitates nutrient uptake10.1111/j.1469-8137.2008.02647.x ↗
88. Solid-phase synthesis of mimosine tetrapeptides and their inhibitory activities on neuraminidase and tyrosinase10.1021/jf203494t ↗
89. Prenylated flavonoids and other constituents from Macaranga indica10.1080/14786419.2019.1662007 ↗
90. Two new 8-isopentenyl isoflavane derivatives from Astragalus dolichochaete Diels10.1080/14786419.2019.1647426 ↗
91. Two new compounds with Nrf2 inducing activity from Glycyrrhiza uralensis. Nat
92. Isoprenylated phenolic compounds from Morus macroura as potent tyrosinase inhibitors10.1055/s-0043-121698 ↗
93. Diels-Alder type adducts with potent alpha-glucosidase inhibitory activity from Morus macroura10.1016/j.phytol.2018.05.035 ↗
94. Bioactive benzofuran derivatives from cortex mori radicis, and their neuroprotective and analgesic activities mediated by mGluR110.3390/molecules22020236 ↗
95. Review of bioactive compounds from root barks of Morus plants (Sang-Bai-Pi) and their pharmacological effects10.1080/23312009.2016.1212320 ↗
96. Identification of two novel prenylated flavonoids in mulberry leaf and their bioactivities10.1016/j.foodchem.2020.126236 ↗
97. Prenylated stilbenes and flavonoids from the leaves of Cajanus cajan
98. A novel alkaloid from Portulaca oleracea L10.1080/14786419.2016.1253081 ↗
99. Isoprenylated flavonoids from Morus nigra and their PPAR γ agonistic activities10.1016/j.fitote.2018.02.004 ↗
100. Phenolic compounds isolated from Morus nigra and their α-glucosidase inhibitory activities10.1080/14786419.2018.1491041 ↗