Tuned morphological electrospun hydroxyapatite nanofibers via pH
Source abstract
Abstract
The concept of biocompatible, osteoconductive and noninflammatory material mimicking the structure of natural bone has generated a considerable interest in recent decades. Hydroxyapatite (HA) is an important bionic material that is used for bone grafting in osseous defects and drug carriers. HA with various morphologies and surface properties have been widely investigated. In this paper, HA nanofibers are produced through a combination of electrospinning and sol-gel technique. The morphologies, composition and structure are investigated by Scanning Electron Microscopy (SEM), Thermogravimetic Analysis (TGA), Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD) patterns, Transmission Electron Microscopy (TEM). The results show that HA nanofibers are even and well-crystallized, and pH is crucial for producing HA nanofibers. With the change of pH from 4 to 9, nanofibers grow densely along (210) plane and become compact while surface area, pore volume and pore size decrease correspondingly. The synthesized HA nanofibers are nontoxic and safe. Zn can be also incorporated into HA nanofibers, which will endow them with more perfect function.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Polymer Nanocomposite Synthesis and Irradiation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (34)
Show source-provided references
1. Zhao Y F, Ma J. Triblock co-polymer templating synthesis of mesostructured hydroxyapatite. Microporous and Mesoporous Materials, 2005, 87, 110–117.10.1016/j.micromeso.2005.07.046 ↗
2. Chen F, Wang Z C, Lin C J. Preparation and characterization of nano-sized hydroxyapatite particles and hydroxyapatite/ chitosan nano-composite for use in biomedical materials. Materials Letters, 2002, 57, 858–861.10.1016/S0167-577X(02)00885-6 ↗
3. Wu X D, Song X F, Li D S, Liu J G, Zhang P B, Chen X S. Preparation of mesoporous nano-hydroxyapatite using a surfactant template method for protein delivery. Journal of Bionic Engineering, 2012, 9, 224–233.10.1016/S1672-6529(11)60105-4 ↗
4. Ramachandra R R, Roopa H N, Kannan T S. Solid state synthesis and thermal stability of HAP and HAP-β-TCP composite ceramic powders. Journal of Materials Science: Materials in Medicine, 1997, 8, 511–518.
5. Cuney T A, Korkusuz F, Timicin M, Akkas N. An investigation of the chemical synthesis and high-temperature sintering behavior of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) bioceramics. Journal of Materials Science: Materials in Medicine, 1997, 8, 91–96.
6. Rhee S H, Tanaka J. Hydroxyapatite coating on a collagen membrane by a miomimetic method. Journal of American Ceramic Society, 1998, 81, 3029–3031.10.1111/j.1151-2916.1998.tb02734.x ↗
7. Liu H S, Chin T S, Lai L S, Chiu S Y, Chung K H, Chang C S, Lui M T. Hydroxyapatite synthesized by a simplified hydrothermal method. Ceramics International, 1997, 23, 19–25.10.1016/0272-8842(95)00135-2 ↗
8. Layrolle P, Ito A, Tateishi T. Sol-gel synthesis of amorphous calcium phosphate and sintering into microporous hydroxyapatite bioceramics. Journal of American Ceramic Society, 1998, 81, 1421–1428.10.1111/j.1151-2916.1998.tb02499.x ↗
9. Jillavenkatesa A, Condrate Sr R A. Sol-gel processing of hydroxyapatite. Journal of Materials Science, 1998, 33, 4111–4119.10.1023/A:1004436732282 ↗
10. Lopatin C M, Pizziconi V, Alford T L, Laursen T. Hydroxyapatite powders and thin films prepared by a sol-gel technique. Thin Solid Films, 1998, 326, 227–232.10.1016/S0040-6090(98)00531-8 ↗
11. Varma H K, Kalkura S N, Sivakumar R. Polymeric precursor route for the preparation of calcium phosphate compounds. Ceramics International, 1998, 24, 467–470.10.1016/S0272-8842(97)00038-2 ↗
12. Kordas G, Trapalis C C. Fourier transform and multi dimensional EPR spectroscopy for the characterization of sol-gel derived hydroxyapatite. Journal of Sol-Gel Science Technology, 1997, 9, 17–24.
13. Cengiz B, Gokce Y, Yildiz N, Aktas Z, Calimli A. Synthesis and characterization of hydroxyapatite nanoparticles. Colloids and Surfaces A, 2008, 322, 29–33.10.1016/j.colsurfa.2008.02.011 ↗
14. Murugan R, Ramakrishna S. Aqueous mediated synthesis of bioresorbable nanocrystalline hydroxyapatite. Journal of Crystal Growth, 2005, 274, 209–213.10.1016/j.jcrysgro.2004.09.069 ↗
15. Webster T J, Ergun C, Doremus R H, Siegel R W, Bizios R. Enhanced functionsof osteoblasts on nanophase ceramics. Biomaterials, 2000, 21, 1803–1810.10.1016/S0142-9612(00)00075-2 ↗
16. Webster T J, Siegel R W, Bizios R. Enhanced surface and mechanical properties of nanophase ceramics to achieve orthopaedic/dental implant efficacy. Bioceramics, 2000, 13, 321–324.
17. Yang P P, Quan Z W, Li C X, Kang X J, Lian H Z, Lin J. Bioactive, luminescent and mesoporous europium-doped hydroxyapatite as a drug carrier. Biomaterials, 2008, 29, 4341–4347.10.1016/j.biomaterials.2008.07.042 ↗
18. Ahn S E, Lee J S, Kim H, Kim S, Kang B H, Kim K H, Kim G T. Photoresponse of sol-gel-synthesized ZnO nanorods. Appied Physics Letters, 2004, 84, 5022–5024.10.1063/1.1763633 ↗
19. Sadasivan S, Khushalani D, Mann S. Synthesis of calcium phosphate nanofilaments in reverse micells. Chemistry of Materials, 2005, 17, 2765–2770.10.1021/cm047926g ↗
20. Han Y J, Kim J, Stucky G D. Preparation of noble metal nanowires using hexagonal mesoporous silica SBA-15. Chemistry of Materials, 2000, 12, 2068–2069.10.1021/cm0010553 ↗
21. Hu S J, Odom T W, Lieber C M. Chemistry and physics in one dimension: Synthesis and properties of nanowires and nanotubes. Accounts of Chemical Research, 1999, 32, 435–445.10.1021/ar9700365 ↗
22. Chen C C, Chao C Y, Lang Z H. Simple solution-phase synthesis of soluble CdS and CdSe nanorods, Chemistry of Materials, 2000, 12, 1516–1518.10.1021/cm9907920 ↗
23. Zhou Z H, Zhou P L, Yang S P, Yu X B, Yang L Z. Controllable synthesis of hydroxyapatite nanocrystals via a dendrimer-assisted hydrothermal process. Materials Research Bulletin, 2007, 42, 1611–1618.10.1016/j.materresbull.2006.11.041 ↗
24. Ma M G, Zhu J F. Solvothermal synthesis and characterization of hierarchically nanostructured hydroxyapatite hollow spheres. European Journal of Inorganic Chemistry, 2009, 2009, 5522–5526.10.1002/ejic.200801134 ↗
25. Mohamed M B, Ismail K Z, Link S, El-Sayer M A. Thermal reshaping of gold nanorods in micelles. Journal of Physical Chemistry B, 1998, 102, 9370–9374.10.1021/jp9831482 ↗
26. Li D, Xia Y N. Electrospinning of nanofibers: Reinventing the wheel?. Advanced Materials, 2004, 16, 1151–1170.10.1002/adma.200400719 ↗
27. Fong H, Chun I, Reneker D H. Beaded nanofibers formed during electrospinning. Polymer, 1999, 40, 4585–4592.10.1016/S0032-3861(99)00068-3 ↗
28. Song X F, Wang Z J, Liu Y B, Wang C, Li L J. A highly sensitive ethanol sensor based on mesoporous ZnO-SnO2 nanofibers. Nanotechnology, 2009, 20, 075501.10.1088/0957-4484/20/7/075501 ↗
29. Song X F, Qi Q, Zhang T, Wang C. A humidity sensor based on KCl-doped SnO2 nanofibers. Sensors and Actuators B, 2009, 138, 368–373.10.1016/j.snb.2009.02.027 ↗
30. Lee K H, Kim H Y, Khil M S, Ra Y M, Lee D R. Characterization of nano-structured poly(e-caprolactone) nonwoven mats via electrospinning. Polymer, 2003, 44, 1287–1294.10.1016/S0032-3861(02)00820-0 ↗
31. Russel S W, Luptak K A, Suchicital C T A, Alford T L, Pizzicoui V B. Chemical and structural evolution of solgel-derived hydroxyapatite thin films under rapid thermal processing. Journal of American Ceramic Society, 1996, 79, 837–842.10.1111/j.1151-2916.1996.tb08514.x ↗
32. Pan H, Darvell B W. Effect of carbonate on hydroxyapatite solubility. Crystal Growth & Design, 2010, 10, 845–850.10.1021/cg901199h ↗
33. Schrotter J C, Cardenas A, Smaihi M, Hovnanian N. Silicon and phosphorus alkoxide mixture: Sol-gel study by spectroscopic techniques. Journal of Sol-Gel Science Technology, 1995, 4, 195–204.10.1007/BF00488374 ↗
34. Tian F, Pan L, Wu X. The NMR studies of the P2O5-SiO2 sol and gel chemistry. Journal of Non-Crystalline Solids, 1988, 104, 129–134.10.1016/0022-3093(88)90191-3 ↗