In vivo biocompatibility of SrO and MgO doped brushite cements
Source abstract
Abstract
Abstract The addition of dopants in biomaterials has emerged as a critical regulator of bone formation and regeneration due to their imminent role in the biological process. The present work evaluated the role of strontium (Sr) and magnesium (Mg) dopants in brushite cement (BrC) on in vivo bone healing performance in a rabbit model. Pure, 1 wt% SrO (Sr‐BrC), 1 wt% MgO (Mg‐BrC), and a binary composition of 1.0 wt% SrO + 1.0 wt% MgO (Sr + Mg‐BrC) BrCs were implanted into critical‐sized tibial defects in rabbits for up to 4 months. The in vivo bone healing of three doped and pure BrC samples was examined and compared using sequential radiological examination, histological evaluations, and fluorochrome labeling studies. The results indicated excellent osseous tissue formation for Sr‐BrC and Sr + Mg‐BrC and moderate bone regeneration for Mg‐BrC compared to pure BrC. Our findings indicated that adding small amounts of SrO, MgO, and binary dopants to the BrC can significantly influence new bone formation for bone tissue engineering.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Spine and Intervertebral Disc Pathology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Veterinary Surgery and Radiology West Bengal University of Animal and Fishery Sciences Kolkata India
W. M. Keck Biomedical Materials Research Laboratory, School of Mechanical and Materials Engineering Washington State University Pullman Washington USA
Funding
National Institute of Dental and Craniofacial Research
References (58)
Show source-provided references
1. 10.1016/j.biomaterials.2005.03.04910.1016/j.biomaterials.2005.03.049 ↗
2. 10.1016/j.actbio.2021.01.00410.1016/j.actbio.2021.01.004 ↗
3. 10.1016/j.actbio.2011.08.00510.1016/j.actbio.2011.08.005 ↗
4. 10.1016/j.actbio.2010.01.03610.1016/j.actbio.2010.01.036 ↗
5. 10.1016/j.biomaterials.2003.08.07310.1016/j.biomaterials.2003.08.073 ↗
6. 10.1016/j.biomaterials.2008.09.03210.1016/j.biomaterials.2008.09.032 ↗
7. 10.3390/ma301051910.3390/ma3010519 ↗
8. 10.1039/b706411j10.1039/b706411j ↗
9. 10.22203/eCM.v020a1410.22203/eCM.v020a14 ↗
10. 10.1002/jbm.b.3166910.1002/jbm.b.31669 ↗
11. 10.1016/j.actbio.2009.10.02110.1016/j.actbio.2009.10.021 ↗
12. 10.1016/j.tibtech.2012.07.00510.1016/j.tibtech.2012.07.005 ↗
13. 10.1016/j.actbio.2008.04.00210.1016/j.actbio.2008.04.002 ↗
14. 10.1016/j.actbio.2011.11.01710.1016/j.actbio.2011.11.017 ↗
15. 10.1016/j.actbio.2007.12.00110.1016/j.actbio.2007.12.001 ↗
16. 10.1016/j.biomaterials.2008.08.02610.1016/j.biomaterials.2008.08.026 ↗
17. 10.1007/s10856‐005‐6986‐310.1007/s10856‐005‐6986‐3 ↗
18. 10.1007/s10439-016-1646-y10.1007/s10439-016-1646-y ↗
19. 10.1016/j.msec.2018.10.07310.1016/j.msec.2018.10.073 ↗
20. 10.1002/jbm.a.3490910.1002/jbm.a.34909 ↗
21. 10.1111/j.1551‐2916.2006.01207.x10.1111/j.1551‐2916.2006.01207.x ↗
22. 10.1016/j.actbio.2010.05.01210.1016/j.actbio.2010.05.012 ↗
23. 10.1016/j.bone.2011.03.68510.1016/j.bone.2011.03.685 ↗
24. 10.1023/A:102550930580510.1023/A:1025509305805 ↗
25. 10.1016/j.jssc.2003.09.01210.1016/j.jssc.2003.09.012 ↗
26. 10.1557/s43578-021-00311-510.1557/s43578-021-00311-5 ↗
27. 10.1002/jbm.b.3323910.1002/jbm.b.33239 ↗
28. 10.1016/S0014‐2999(02)02040‐X10.1016/S0014‐2999(02)02040‐X ↗
29. 10.1007/s00198‐004‐1753‐810.1007/s00198‐004‐1753‐8 ↗
30. 10.1002/jbm.b.3189310.1002/jbm.b.31893 ↗
31. Study on reconstruction of rabbit alveolar bone defect with strontium‐containing brushite bone cements
32. 10.1016/j.msec.2017.05.11710.1016/j.msec.2017.05.117 ↗
33. American Bone Healthhttps://americanbonehealth.org/medications-bone-health/why-strontium-is-not-advised-for-bone-health/(Accessed on May 19 2022).
34. 10.1016/j.msec.2012.09.01710.1016/j.msec.2012.09.017 ↗
35. 10.1007/s10853-016-0017-210.1007/s10853-016-0017-2 ↗
36. 10.1016/j.msec.2015.10.09210.1016/j.msec.2015.10.092 ↗
37. 10.1016/j.actbio.2009.04.02410.1016/j.actbio.2009.04.024 ↗
38. 10.1016/j.msec.2012.05.02010.1016/j.msec.2012.05.020 ↗
39. 10.1111/j.1151‐2916.1996.tb08746.x10.1111/j.1151‐2916.1996.tb08746.x ↗
40. 10.1016/j.ceramint.2011.01.00510.1016/j.ceramint.2011.01.005 ↗
41. 10.1021/acsbiomaterials.9b0042210.1021/acsbiomaterials.9b00422 ↗
42. 10.1023/A:101858370633510.1023/A:1018583706335 ↗
43. 10.1023/A:102036790077310.1023/A:1020367900773 ↗
44. 10.2106/00004623-200310000-0001010.2106/00004623-200310000-00010 ↗
45. 10.1007/s10856‐010‐4221‐310.1007/s10856‐010‐4221‐3 ↗
46. 10.1016/j.smallrumres.2007.09.00610.1016/j.smallrumres.2007.09.006 ↗
47. 10.1016/j.biomaterials.2011.01.00410.1016/j.biomaterials.2011.01.004 ↗
48. 10.1016/S0142‐9612(03)00293‐X10.1016/S0142‐9612(03)00293‐X ↗
49. Osteoblast differentiation and bone formation gene expression in strontium‐inducing bone marrow mesenchymal stem cell
50. 10.1038/3507909210.1038/35079092 ↗
51. 10.1016/S0021‐9290(03)00124‐610.1016/S0021‐9290(03)00124‐6 ↗
52. 10.1016/j.actbio.2009.12.03710.1016/j.actbio.2009.12.037 ↗
53. 10.1002/jbm.a.3418110.1002/jbm.a.34181 ↗
54. 10.1002/jbm.1027010.1002/jbm.10270 ↗
55. 10.1359/jbmr.1997.12.8.118910.1359/jbmr.1997.12.8.1189 ↗
56. 10.1038/372786a010.1038/372786a0 ↗
57. 10.1016/j.bone.2011.06.00510.1016/j.bone.2011.06.005 ↗
58. 10.1038/nature0165810.1038/nature01658 ↗