journal article·2014-06-18Open access

Antimicrobial nanospheres thin coatings prepared by advanced pulsed laser technique

Alina Maria Holban, Valentina Grumezescu, Alexandru Mihai Grumezescu, Bogdan Ştefan Vasile, Roxana Truşcă, Rodica Cristescu, Gabriel Socol, Florin Iordache

Abstract

We report on the fabrication of thin coatings based on polylactic acid-chitosan-magnetite-eugenol (PLA-CS-Fe3O4@EUG) nanospheres by matrix assisted pulsed laser evaporation (MAPLE). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) investigation proved that the homogenous Fe3O4@EUG nanoparticles have an average diameter of about 7 nm, while the PLA-CS-Fe3O4@EUG nanospheres diameter sizes range between 20 and 80 nm. These MAPLE-deposited coatings acted as bioactive nanosystems and exhibited a great antimicrobial effect by impairing the adherence and biofilm formation of Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) bacteria strains. Moreover, the obtained nano-coatings showed a good biocompatibility and facilitated the normal development of human endothelial cells. These nanosystems may be used as efficient alternatives in treating and preventing bacterial infections.
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Research context

OpenAlex topics: Laser-Ablation Synthesis of Nanoparticles · Nonlinear Optical Materials Studies · Laser Material Processing Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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