DataVXJournal of Biomedical Materials Research Part B: Applied BiomaterialsPaper
journal article·2021-07

Fabrication of bioactive novel scaffold by solid‐state reaction sintering for bone regeneration

Erika López, Yrina Viatela, Miguel Prado, Vanesa Biolatti, Carolina Bagnatto

Journal of Biomedical Materials Research Part B: Applied Biomaterials· Volume 109· Issue 7
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Source abstract

Abstract

Abstract In this work we present a new type of scaffold obtained by solid‐state reaction, simultaneous sintering of a mixture of precursor oxides, carbonates, and organic substances, the latter used for pore generation. Having variable local composition, exhibits excellent overall physicochemical and bioactivity response. Open porosity is about 50%–60% and its permeability 10−11 m2. X‐ray diffraction exhibits the presence of a sodium‐calcium silicate and sodium‐calcium phosphate crystalline phases. Additionally, by mechanical compression tests the range of failure stress obtained for the scaffolds was 0.3–1.1 MPa. The bioactivity and dissolution rate of the scaffolds were evaluated by in vitro tests. After 1 week soaking in simulated body fluid, the formation of a continuous hydroxyapatite layer, which does not differentiate local compositions, was observed. Our results from cell culture tests clearly indicate that during hydroxyapatite layer formation, scaffolds do not liberate any cytotoxic substances. Moreover, cells seeded in the hydroxyapatite‐covered scaffolds grew better than the control.
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Research context

Ceramics & glassesBiomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Calcium Carbonate Crystallization and Inhibition · Orthopaedic implants and arthroplasty

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centro Atómico Constituyentes Instituto Sábato (UNSAM, CNEA) Comisión Nacional de Energía Atómica (CNEA) Av. Gral. Paz 1499 Buenos Aires Prov. Buenos Aires B1650KNA Argentina

División Aplicaciones Médicas e Industriales Departamento Materiales Nucleares Centro Atómico Barilcohe Comisión Nacional de Energía Atómica(CNEA) Av. Bustillo 9500 S. C. de Bariloche Río Negro R8402AGP Argentina

Instituo Balseiro Universidad Nacional de Cuyo S. C. de Bariloche Río Negro R8400AGP Argentina

Consejo Nacional de Investigaciones Científicas y Técnicas Bariloche Río Negro R8402AGP Argentina

Comisión Nacional de Energía Atómica (CNEA), Centro de Medicina Nuclear y Radioterapia‐Instituto de Tecnologías Nucleares para la Salud (INTECNUS); Laboratorio de Radiobiología y Biodosimetría, S.C. de Bariloche Río Negro Argentina

Instituto de Energía y Desarrollo Sustentable Centro Atómico Bariloche Comisión Nacional de Energía Atómica S. C. de Bariloche Río Negro R8402AGP Argentina

Funding

Comisión Nacional de Energía Atómica, Gobierno de Argentina

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