DataVXJournal of Biomedical Materials Research Part APaper
journal article·2018-02

Nanofibrous scaffolds with biomimetic structure

Shahla Khalili, Saied Nouri Khorasani, Mohammad Razavi, Batol Hashemi Beni, Fariba Heydari, Ali Tamayol

Journal of Biomedical Materials Research Part A· Volume 106· Issue 2
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Source abstract

Abstract

Abstract This research studies the effect of using a grid‐like pattern as a collector on increasing the pore size of the electrospun gelatin/cellulose acetate/elastin scaffolds. The morphological study showed an enlargement in pore size and a decline in fiber diameter in comparison with the scaffold fabricated using conventional flat sheet collectors. The use of the pattern increased the swelling ratio and degradation rate of the scaffold. Investigating the tensile properties of scaffolds revealed that the patterned collector increased the elongation at break up to 145%. In vitro experiments revealed the patterned scaffold as a good substrate for attachment and proliferation of fibroblast cells. Overall, our results indicated that the patterned scaffold of gelatin/cellulose acetate/elastin could provide a better microenvironment for fibroblast cells compared to the conventional scaffolds. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 370–376, 2018.
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Research context

Nanomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · Additive Manufacturing and 3D Printing Technologies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering Isfahan University of Technology Isfahan 84156‐83111 Iran

Center for Biomedical Engineering, Department of Medicine Brigham and Women's Hospital, Harvard Medical School Boston Massachusetts 02139

Harvard‐ MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge Massachusetts 02139

Department of Oral and Maxillofacial Pathology School of Dentistry, Isfahan University of Medical Sciences Isfahan 81746‐73461 Iran

Torabinejad Dental Sciences Research Center, School of Dentistry, Isfahan University of Medical Sciences Isfahan 81746‐73461 Iran

Department of Anatomical Sciences Medical School, Isfahan University of Medical Sciences Isfahan 81746‐73461 Iran

References (20)

Show source-provided references
1. 10.1021/la104206h10.1021/la104206h ↗
2. 10.1002/adma.20160606110.1002/adma.201606061 ↗
3. 10.1007/s10856-017-5874-y10.1007/s10856-017-5874-y ↗
4. 10.1016/j.biomaterials.2011.05.06510.1016/j.biomaterials.2011.05.065 ↗
5. 10.1134/S0965545X1603009310.1134/S0965545X16030093 ↗
6. Increasing the pore size of electrospun scaffolds
7. 10.1016/j.actbio.2011.02.03610.1016/j.actbio.2011.02.036 ↗
8. 10.4161/cam.4.3.1174710.4161/cam.4.3.11747 ↗
9. 10.1002/adma.20080309210.1002/adma.200803092 ↗
10. 10.1089/ten.teb.2011.039010.1089/ten.teb.2011.0390 ↗
11. 10.1021/bm800565u10.1021/bm800565u ↗
12. 10.1016/j.matlet.2008.12.04210.1016/j.matlet.2008.12.042 ↗
13. KhaliliS Nouri KhorasaniS.Design fabrication and characterization of electrospun nanofibers of gelatin/cellulose acetate/elastin scaffold for skin tissue engineering application(PhD Thesis); Isfahan University of Technology 2017.
14. 10.1371/journal.pone.005715710.1371/journal.pone.0057157 ↗
15. 10.1371/journal.pone.005633010.1371/journal.pone.0056330 ↗
16. 10.1002/adfm.20170343710.1002/adfm.201703437 ↗
17. 10.1016/j.biomaterials.2009.09.07210.1016/j.biomaterials.2009.09.072 ↗
18. 10.1002/jbm.a.3048710.1002/jbm.a.30487 ↗
19. 10.5114/pdia.2013.3835910.5114/pdia.2013.38359 ↗
20. The biomechanical properties of skin