A mouse strain difference in tumorigenesis induced by biodegradable polymers
Source abstract
Abstract
Abstract The use of poly‐L‐lactic acid (PLLA) surgical implants for repair of bone fractures has gained popularity in the past decade. The aim of this study was to evaluate the in vivo effect of PLLA plates on subcutaneous tissue in two mouse strains, BALB/cJ and SJL/J, which have higher and lower tumorigenicity, respectively. Gap‐junctional intercellular communication and protein expression of connexin 43 were significantly suppressed, whereas secretion of transforming growth factor‐β1 and expression of extracellular matrix, insulin‐like growth factor binding protein 3, and cysteine‐rich intestinal protein 2 were significantly increased in PLLA‐implanted BALB/cJ mice when compared with BALB/cJ controls. Finally, tumors were formed after implantation of cultured cells from the more‐tumorigenic BALB/cJ, but not SJL/J, mice into nude mice. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res, 2006
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Research context
OpenAlex topics: Connexins and lens biology · Heat shock proteins research · Wnt/β-catenin signaling in development and cancer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (38)
Show source-provided references
1. Hayashi T · 1993 · 17
2. 10.1002/jbm.82029090910.1002/jbm.820290909 ↗
3. 10.1093/ajcp/103.4.46610.1093/ajcp/103.4.466 ↗
4. Imai Y · 1993 · 53
5. 10.1016/S0142-9612(97)00012-410.1016/S0142-9612(97)00012-4 ↗
6. A comparison of fibrous tissue formation surrounding intraperitoneal and subcutaneous implantation of ALCAP, HA, and TCP ceramic devices
7. 10.1001/archsurg.1966.0133005014302310.1001/archsurg.1966.01330050143023 ↗
8. A biological comparison of polyglactin 910 and polyglycolic acid synthetic absorbable sutures
9. 10.1002/jbm.82028010410.1002/jbm.820280104 ↗
10. 10.1002/jbm.82026050610.1002/jbm.820260506 ↗
11. 10.1016/0024-3205(93)90606-410.1016/0024-3205(93)90606-4 ↗
12. 10.2741/A27510.2741/A275 ↗
13. 10.1078/0171-9335-0008010.1078/0171-9335-00080 ↗
14. 10.1080/0968768021013983910.1080/09687680210139839 ↗
15. 10.1111/j.1432-1033.1996.0001q.x10.1111/j.1432-1033.1996.0001q.x ↗
16. 10.1016/0304-419X(79)90002-710.1016/0304-419X(79)90002-7 ↗
17. 10.1016/0166-2236(89)90150-110.1016/0166-2236(89)90150-1 ↗
18. Role of inhibition of intercellular communication in carcinogenesis
19. 10.1002/mc.294007010310.1002/mc.2940070103 ↗
20. 10.1083/jcb.115.5.135710.1083/jcb.115.5.1357 ↗
21. 10.1016/0092-8674(93)90728-910.1016/0092-8674(93)90728-9 ↗
22. 10.1002/jbm.a.3009010.1002/jbm.a.30090 ↗
23. Foreign‐body tumors of mice: Strain and sex differences in latency and incidence10.1093/jnci/58.5.1443 ↗
24. 10.1016/0014-4827(87)90014-010.1016/0014-4827(87)90014-0 ↗
25. 10.1002/jbm.82029011610.1002/jbm.820290116 ↗
26. 10.1163/15685620074412910.1163/156856200744129 ↗
27. 10.1002/(SICI)1097-4636(19970605)35:3<391::AID-JBM13>3.0.CO;2-I10.1002/(SICI)1097-4636(19970605)35:3<391::AID-JBM13>3.0.CO;2-I ↗
28. 10.1083/jcb.111.5.207710.1083/jcb.111.5.2077 ↗
29. 10.1006/abbi.2000.213110.1006/abbi.2000.2131 ↗
30. 10.1111/j.1349-7006.1998.tb03287.x10.1111/j.1349-7006.1998.tb03287.x ↗
31. 10.1186/1471-2121-2-1410.1186/1471-2121-2-14 ↗
32. 10.1152/ajprenal.00007.200310.1152/ajprenal.00007.2003 ↗
33. 10.1136/thorax.58.9.77210.1136/thorax.58.9.772 ↗
34. 10.1016/S0303-7207(01)00390-210.1016/S0303-7207(01)00390-2 ↗
35. Effect of human osteopontin on proliferation, transmigration and expression of MMP‐2 and MMP‐9 in osteosarcoma cells
36. Insulin‐like growth factor binding protein‐3 and insulin receptor substrate‐1 in breast cancer: Correlation with clinical parameters and disease‐free survival
37. 10.1086/31591710.1086/315917 ↗
38. 10.1006/cyto.2001.100810.1006/cyto.2001.1008 ↗