Study of the Properties and Cells Growth on Antibacterial Electrospun Polycaprolactone/Cefuroxime Scaffolds
Source abstract
Abstract
Abstract Electrospun materials are good candidates for the design of tissue regeneration scaffolds as they can simulate the natural surroundings of tissue cells. The study proposes electrospun polycaprolactone (PCL)/cefuroxime (CFU) scaffolds for human cell culture and investigates the influence of the antibiotic content on scaffold morphology, thermal and mechanical properties. The increase in the CFU concentration resulted in the reduction of fiber diameter and number of deformations. It also influenced the reduction of scaffold thermal enthalpies and improved scaffold break strength. With regard to cell growth, the scaffolds showed precedence in greater colonization of the HeLa cells. Finally, these scaffolds showed compatibility with standard human cell lines, and thus they can be used for the repair of damaged tissues.
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Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
University of Zagreb Faculty of Textile Technology, Department of Fundamental Natural and Engineering Sciences , Prilaz baruna Filipovića 28a , Zagreb , Croatia
University of Zagreb Faculty of Chemical Engineering and Technology, Department of Polymer Engineering and Organic Chemical Technology , Marulićev Trg 19 , Zagreb , Croatia
University of Zagreb Faculty of Food Technology and Biotechnology, Department of Biochemical Engineering , Pierottijeva ul. 6 , Zagreb , Croatia
Specialty Eye Hospital Svjetlost , Heinzelova ul. 39 , Zagreb and Department of Ophthalmology Medical Faculty , University of Rijeka , Braće Branchetta 20/1 , Rijeka , Croatia
University of Zagreb , Faculty of Metallurgy, Department of Physical Metallurgy , Aleja narodnih heroja 3, Sisak , , Croatia
Materials’ Research Center METRIS , Zagrebačka 30 , Pula , Croatia
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