Blend Electrospinning of Poly(Ɛ-Caprolactone) and Poly(Ethylene Glycol-400) Nanofibers Loaded with Ibuprofen as a Potential Drug Delivery System for Wound Dressings
Source abstract
Abstract
Abstract Electrospinning (ES) is a versatile and diverse technique to fabricate nano and micro fibers that could be utilized as drug delivery systems. The aim of this research was the fabrication and characterization of drug loaded nanofibrous scaffold produced by single-needle ES using poly(Ɛ-caprolactone) (PCL) and poly(ethylene glycol-400) (PEG) and to investigate the potential of this material as a drug delivery system. A model drug, Ibuprofen (IBU), was used. Ibuprofen is a medicine that is a non-steroidal, anti-inflammatory drug (NSAID). Two concentrations of IBU, 5 wt% and 7 wt%, were incorporated for the ES of PCL and PCL/PEG nanofibers. Characterization of nanofibers was done by using Scanning Electron Microscopy (SEM), Differential Scanning Calorimeter (DSC), Thermogravimetric Analysis (TGA), and Water Contact Angle Measurements. The impact of IBU on nanofibers’ properties such as morphology, diameters, hydrophilicity, and tensile strength was investigated. Finally, the drug release kinetics of IBU from nanofibers was analyzed and their percentage release efficiency of IBU (RE%) was determined by UV-vis spectroscopy during 24 h.
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Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Silk-based biomaterials and applications · Advanced Sensor and Energy Harvesting Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Laboratoire de Photochimie et d’Ingenierie Macromoleculaires, 3-bis rue Alfred Werner , Université de Haute Alsace , Mulhouse , France
Laboratoire de Physique et Mecanique Textiles, 11 rue Alfred Werner , Université de Haute Alsace , Mulhouse , France
Department of Textile Engineering and Technology , University of the Punjab , Lahore , Pakistan
Faculty of Dental Medicine , Str. Pacurari Nr.11 , University “Apollonia” , Iasi , Romania
References (34)
Show source-provided references
1. Sidgwick, G. P., McGeorge, D., Bayat, A. (2015). A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Archives of Dermatological Research, 307, 461–477.10.1007/s00403-015-1572-0 ↗
2. Abrigo, M., McArthur, S. L., Kingshott, P. (2014). Electrospun nanofibers as dressings for chronic wound care: Advances, challenges and future prospects. Macromolecular Bioscience, 14, 772–792.10.1002/mabi.201300561 ↗
3. Boateng, J. S., Matthews, K. H., Stevens, H. N. E., Eccleston, G. M. (2008). Wound healing dressings and drug delivery systems: A review. Journal of Pharmaceutical Sciences, 97, 2892–2923.10.1002/jps.21210 ↗
4. Aragón, J., Costa, C., Coelhoso, I., Mendoza, G., Aguiar-Ricardo, A., et al. (2019). Electrospun asymmetric membranes for wound dressing applications. Journal of Material Science & Engineering C, 103, 109822.10.1016/j.msec.2019.109822 ↗
5. Bhardwaj, N., Kundu, S. C. (2010). Electrospinning: A fascinating fiber fabrication technique. Biotechnology Advances, 28, 325–347.10.1016/j.biotechadv.2010.01.004 ↗
6. Liao, N., Unnithan, A. R., Joshi, M. K., Tiwari, A. P., Hong, S. T., et al. (2015). Electrospun bioactive poly(Ɛ-caprolactone)-cellulose acetate-dextran antibacterial composite mats for wound dressing applications. Colloids and Surfaces A, 469, 194–201.10.1016/j.colsurfa.2015.01.022 ↗
7. Pankongadisak, P., Sangklin, S., Chuysinuan, P., Suwantong, O., Supaphol, P. (2019). The use of electrospun curcumin-loaded poly(L-lactic acid) fiber mats as wound dressing materials. Journal of Drug Delivery Science and Technology, 536, 101–121.10.1016/j.jddst.2019.06.018 ↗
8. Goyal, R., Macri, L. K., Kaplan, H. M., Kohn, J. (2016). Nanoparticles and nanofibers for topical drug delivery. Journal of Controlled Release, 240, 77–92.10.1016/j.jconrel.2015.10.049 ↗
9. Rodríguez-Tobías, H., Morales, G., Grande, D. (2019). Comprehensive review on electrospinning techniques as versatile approaches toward antimicrobial biopolymeric composite fibers. Material Science and Engineering C, 101, 306–322.10.1016/j.msec.2019.03.099 ↗
10. Doustangi, A. (2015). Effect of electrospinning process parameters of polycaprolactone and nanohydroxyapatite nanocomposite nanofibers. Textile Research Journal, 85, 1445–1454.10.1177/0040517514566109 ↗
11. Beachley, V., Wen, X. (2009). Effect of electrospinning parameters on the nanofiber diameter and length. Material Science and Engineering C, 29, 663–668.10.1016/j.msec.2008.10.037 ↗
12. Li, W., Shi, I., Zhang, X., Liu, K., Ismat Ullah, Cheng, P. (2018). Journal of Applied Polymer Science, 135.10.1002/app.45578 ↗
13. Huang, Z. M., Zhang, Y. Z., Kotaki, M., Ramakrishn, S. (2003). A review on polymer nanofibers by electrospinning and their applications in nanocpomposites. Composites Science and Technology, 63, 2223–2253.10.1016/S0266-3538(03)00178-7 ↗
14. Dash, T. K., Konkimalla, V. B. (2012). Poly-e-caprolactone based formulations for drug delivery and tissue engineering: A review. Journal of Controlled Release, 158, 15–33.10.1016/j.jconrel.2011.09.064 ↗
15. Woodruff, M. A., Hutmacher, D. (2010). The return of a forgotten polymer—polycaprolactone in the 21st century. Progress in Polymer Science, 35, 1217–1256.10.1016/j.progpolymsci.2010.04.002 ↗
16. Elnakady, Y. A., AlRez, M. F., Fouad, H., Abuelreich, S., Albarrag, A. M., et al. (2015). Vascular tissue engineering using polycaprolactone nanofibrous scaffolds fabricated via electrospinning. Science of Advanced Materials, 7, 407–413.10.1166/sam.2015.2252 ↗
17. Detta, N., Brown, T. D., Edin, F. K., Albrecht, K., Chiellini, E., et al. (2010). Melt electrospinning of polycaprolactone and its blends with poly(ethylene glycol). Polymer International, 59, 1558–1562.10.1002/pi.2954 ↗
18. Chena, C. H., Chen, S. H., Shalumona, K. T., Chena, J. P. (2015). Prevention of peritendinous adhesions with electrospun polyethylene glycol/polycaprolactone nanofibrous membranes. Colloids and Surfaces B: Biointerfaces, 133, 221–230.10.1016/j.colsurfb.2015.06.012 ↗
19. Bui, H. T., Chung, O. H., Cruz, J. D., Park, J. S. (2014). Fabrication and characterization of electrospun curcumin-loaded polycaprolactone-polyethylene glycol nanofibers for enhanced wound healing. Macromolecular Research, 22, 1288–1296.10.1007/s13233-014-2179-6 ↗
20. Repanas, A., Wolkers, W. F., Gryshkov O., Müller, M., Glasmacher, B. (2015). PCL/PEG electrospun fibers as drug carriers for the controlled delivery of dipyridamole. Journal of In Silico & In Vitro Pharmacology, 1, 1–10.
21. Iurea, D. M., Popa, M., Chailan, J. F., Tamba, B. I., Todorancea, I., et al. Journal of Bioactive and Compatible Polymers, 28, 368–384.
22. Li, J., Kuang, Y., Shi, J., Gao, Y., Zhou, J., et al. (2013). D-amino acids boost the selectivity and confer supramolecular hydrogels of a nonsteroidal anti-inflammatory drug (NSAID). The Journal of Organic Chemistry, 135, 542–545.10.1021/ja310019x ↗
23. Li, F., Zhao, Y., Song, Y., Kumar, A. (2010). Nanofibers. IntechOpen.
24. Kolbu, D., Guimond-Lischer, S., Sajkiewicz, P., Maniura-Weber K., Fortunato G. (2015). The effect of selected electrospinning parameters on molecular structure of polycaprolactone nanofibers. International Journal of Polymeric Materials and Polymeric Biomaterials, 64, 365–377.10.1080/00914037.2014.945209 ↗
25. Qin, X., Wu, D. (2010). Effect of different solvents on poly(caprolactone) (PCL) electrospun nonwoven membranes. Journal of Thermal Analysis and Calorimetry, 107, 1007–1013.10.1007/s10973-011-1640-4 ↗
26. Angammana, C. J., Jayaram, S. H. (2011). Analysis of the effects of solution conductivity on electrospinning process and fiber morphology. IEEE Transactions on Industry Applications, 47, 1109–1117.10.1109/TIA.2011.2127431 ↗
27. Ferreira, J. L., Gomes, S., Henriques, C., Borges, J. P., Silva, J. C. (2014). Electrospinning polycaprolactone dissolved in glacial acetic acid. Journal of Applied Polymer Science, 131.10.1002/app.41068 ↗
28. Patankar, N. A. (2004). Mimicking the lotus effect: Influence of double roughness structures and slender pillars. ACS Publications, 20, 8209–8213.10.1021/la048629t ↗
29. Tiwari, A. P., Joshi, M. K., Lee, J., Maharjan, B., Ko, S. W., et al. (2017). Colloids and Surfaces A: Physiochemical and Engineering Aspects, 520, 105–113.10.1016/j.colsurfa.2017.01.054 ↗
30. Guan, J., Wagner, W. R. (2005). Synthesis, characterization and cytocompatibility of polyurethaneurea elastomers with designed elastase sensitivity. Biomacromolecules, 6, 2833–2842.10.1021/bm0503322 ↗
31. Wang, X., Zhao, H., Turng, L. S., Li, Q. (2013). Crystalline morphology of electrospun poly(ɛ-caprolactone) (PCL) nanofibers. Journal of Industrial Engineering Chemistry Research, 52, 4939–4949.10.1021/ie302185e ↗
32. Shi, Y., Wei, Z., Zhao, H., Liu, T., Dong, A., et al. (2013). Electrospinning of ibuprofen-loaded composite nanofibers for improving the performances of transdermal patches. Journal of Nanoscience and Nanotechnology, 13, 3855–3863.10.1166/jnn.2013.7157 ↗
33. Karavasili, C., Bouropoulos, N., Kontopoulou, I., Smith, A., Merwe, S. M., et al. (2014). Preparation and characterization of multiactive electrospun fibers: poly-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs. Journal of Biomedical Materials Research, 102, 2583–2589.10.1002/jbm.a.34931 ↗
34. Potrc, T., Baumgartner, S., Roskar, R., Planinsek, O., Lavric, Z., et al. (2015). Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs. European Journal of Pharmaceutical Sciences, 75, 101–113.10.1016/j.ejps.2015.04.004 ↗