Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology
Source abstract
Abstract
Abstract Heart failure (HF) is one of the leading causes for hospital admissions worldwide. HF patients are classified based on the chronic changes in left ventricular ejection fraction (LVEF) as preserved (LVEF ≥ 50%), reduced (LVEF ≤ 40%), or mid‐ranged (40% < LVEF < 50%) HFs. Treatments nowadays can prevent HFrEF progress, whereas only a few of the treatments have been proven to be effective in improving the survival of HFpEF. In this review, numerous mediators involved in the pathogenesis of HF are summarized. The regional upstream signaling and their diagnostic and therapeutic potential are also discussed. Additionally, the recent challenges and development in cardiac regenerative therapy that hold opportunities for future research and clinical translation are discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Cardiac Fibrosis and Remodeling · Cardiac Structural Anomalies and Repair
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Molecular Biomedical Sciences and Comparative Medicine Institute North Carolina State University Raleigh NC 27607 USA
Joint Department of Biomedical Engineering University of North Carolina at Chapel Hill & North Carolina State University Raleigh NC 27607 USA
Funding
National Institutes of Health · American Heart Association
References (100+)
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