DataVXJournal of Biomaterials Science, Polymer EditionPaper
journal article·2008-01

Preparation and characterization of nano-hydroxyapatite/silk fibroin porous scaffolds

Lin Liu, Jinying Liu, Mingqi Wang, Sijia Min, Yurong Cai, Liangjun Zhu, Juming Yao

Journal of Biomaterials Science, Polymer Edition· Volume 19· Issue 3
Publisher page
Source abstract

Abstract

Novel tissue engineering scaffold materials of nano-hydroxyapatite (nHA)/silk fibroin (SF) biocomposite were prepared by freeze-drying. The needle-like nHA crystals of about 10 nm in diameter by 50-80 nm in length, which were uniformly distributed in the porous nHA/SF scaffolds, were prepared by a co-precipitation method with a size. The as-prepared nHA/SF scaffolds showed good homogeneity, interconnected pores and high porosity. XRD and FT-IR analysis suggested that the silk fibroin was in beta-sheet structure, which usually provides outstanding mechanical properties for silk materials. In this work, composite scaffolds containing as high as 70% (w/w) nHA were prepared, which had excellent compressive modulus and strength, higher than the scaffolds at low nHA content level and other porous biodegradable polymeric scaffolds often considered in bone-related tissue engineering reported previously. The cell compatibility of composite scaffolds was evaluated through cell viability by MTT assay. All these results indicated that these nHA/SF scaffold materials may be a promising biomaterial for bone tissue engineering.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterialsComposites

OpenAlex topics: Silk-based biomaterials and applications · Bone Tissue Engineering Materials · Periodontal Regeneration and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

a The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Xiasha Higher Education Park, Hangzhou 310018, P.R. China

b The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Xiasha Higher Education Park, Hangzhou 310018, P.R. China

c The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Xiasha Higher Education Park, Hangzhou 310018, P.R. China

d College of Animal Sciences, Zhejiang University, Hangzhou 310029, P.R. China

e The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Xiasha Higher Education Park, Hangzhou 310018, P.R. China

f College of Animal Sciences, Zhejiang University, Hangzhou 310029, P.R. China

g The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Xiasha Higher Education Park, Hangzhou 310018, P.R. China

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