Synthesis and Characterization of Thermo-Sensitive Radio-Opaque Poly(N-Isopropylacrylamide-co-PEG-2-Iodobenzoate)
Source abstract
Abstract
Radiopacity is required for embolic materials to be monitored by angiography during embolization. Covalently bound radio-opaque biomaterials would be ideal for embolization. Poly(N-isopropylacrylamide-co-PEG-acrylate) modified with 2-iodobenzoyl chloride was synthesized and characterized by (1)H-NMR, differential scanning calorimetry and X-ray opacity. Poly(N-isopropylacrylamide-co-PEG-2-iodobenzoate) shows radiopacity, as well as thermo-sensitivity. Cytotoxicity testing on these co-polymers shows little cytotoxicity. Phase-transition temperature and radiopacity varied according to the content of NIPAAm and 2-iodobenzoate. Increasing the content of 2-iodobenzoate raised the radiopacity and lowered the LCST.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lanthanide and Transition Metal Complexes · Intracranial Aneurysms: Treatment and Complications · Hydrogels: synthesis, properties, applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
a Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA
b Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA
c Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA
d Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA
e Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, USA. Brent.Vernon@asu.edu
References (14)
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