Review Physicochemical and immunological basis of silicone pathophysiology
Source abstract
Abstract
Silicones, model biomaterials with almost ubiquitous applications, are the focus of a contentious debate. In this review, we will consider both established physicochemical phenomena and immunological phenomena; and then consider the human clinical phenomena that relate directly to them. We will explore the two competing theories of the biological activity of silicones, and we will discuss the weaknesses in the various arguments that silicone is inert. We conclude that from a pathophysiological perspective, silicones should be expected to be bioactive materials and that the physicochemical and immunological data at the experimental level are compelling.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Cellular Mechanics and Interactions · Cell Adhesion Molecules Research · Occupational and environmental lung diseases
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
a Biomaterials Bioreactivity Characterization Laboratory, Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90024-1732, USA
b Biomaterials Bioreactivity Characterization Laboratory, Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90024-1732, USA
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