Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation (Adv. Biology 5/2022)

Junjie Gao; Hong Mei; Jing Sun; Hao Li; Yuege Huang; Yanhong Tang; Linwei Duan; Delin Liu; Yidan Pang; Qiyang Wang; Youshui Gao; Ke Song; Jincun Zhao; Changqing Zhang; Jia Liu

doi:10.1002/adbi.202270051

journal article·2022-05Open access

Neuropilin‐1‐Mediated SARS‐CoV‐2 Infection in Bone Marrow‐Derived Macrophages Inhibits Osteoclast Differentiation (Adv. Biology 5/2022)

Junjie Gao, Hong Mei, Jing Sun, Hao Li, Yuege Huang, Yanhong Tang, Linwei Duan, Delin Liu, Yidan Pang, Qiyang Wang, Youshui Gao, Ke Song, Jincun Zhao, Changqing Zhang, Jia Liu

Advanced Biology· Volume 6· Issue 5

Publisher page Open full text

Source abstract

Abstract

Bone Marrow-Derived Macrophages SARS-CoV-2 In article 2200007, Zhao, Zhang, Liu, and co-workers teamed up to investigate SARS-CoV-2 infection in bone marrow-derived macrophages (BMMs). They find that SARS-CoV-2 infects BMMs in a neuropilin-1 (NRP1)-dependent manner (insert: red, SARS-CoV-2 and its spike protein; green, BMM and its NRP1 protein). Interestingly, SARS-CoV-2 infection could inhibit the differentiation of BMMs into osteoclasts (bottom, blue).

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Research context

OpenAlex topics: Biomarkers in Disease Mechanisms · Immune cells in cancer · Mesenchymal stem cell research

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