Composite PLA scaffolds reinforced with PDO fibers for tissue engineering
Source abstract
Abstract
Novel composite scaffolds were produced using long continuous bidirectional fibers embedded in an electrospun matrix, with the aim of using them in soft tissue engineering applications. The fibers are of polydioxanone and the matrix of polylactic acid. The novel manufacturing method consists of direct electrospinning performed on both sides of a collector that supports the already arranged fibers. The scaffolds were tested in vitro using 3T3 mouse fibroblasts as-obtained or functionalized with biotin or poly (dopamine). Functionalization did not significantly affect cells attachment, metabolic activity, or proliferation, but poly (dopamine) was proven to be effective in inducing hydrophilicity to the surface.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine · biodegradable polymer synthesis and properties
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Materials Science and Technology, Faculty of Materials and Environment Engineering, Technical University of Cluj-Napoca, Cluj-Napoca, Romania
Division of Materials, Mechanics and Structures, Faculty of Engineering, University of Nottingham, Nottingham, UK
Physics Faculty and Interdisciplinary Research Institute in Bio-Nano-Science, Babes-Bolyai University, Cluj-Napoca, Romania
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