journal article·1987-04

Hemocompatibility of Hydrogel with Polyethyleneoxide Chains

Akimasa Nakao, Shoji Nagaoka, Yuichi Mori

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Abstract

We have synthesized a hydrogel with long polyethyleneoxide (PEO) chains and evaluated its hemocompatibility. The hydrogel significantly suppressed the adsorption of plasma proteins and adhesion of platelets. In addition, the marked retardation of thrombus formation on its surface was recognized. These findings seems to be caused by the volume restriction effects derived from the highly flexible and hydrophilic PEO chains.
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Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · Polymer Surface Interaction Studies · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Assistant Professor Second Department of Surgery Nagoya University School of Medicine Nagoya, Japan

Research Associates Basic Research Laboratories 7bray Industries, Inc. Kamakura, Japan

References (14)

Show source-provided references
1. 10.1097/00002480-197301900-0000110.1097/00002480-197301900-00001 ↗
2. Leonard, E.F. · 1976
3. 10.1002/jbm.82009051110.1002/jbm.820090511 ↗
4. Pennington, C.J. · 1971
5. 10.1111/j.1749-6632.1977.tb41781.x10.1111/j.1749-6632.1977.tb41781.x ↗
6. 10.1002/polc.507066013410.1002/polc.5070660134 ↗
7. Abuchowski, A. · J. Biol. Chem. · 1977 · 252 · 357810.1016/S0021-9258(17)40291-2 ↗
8. 10.1295/koron.38.57110.1295/koron.38.571 ↗
9. Mori, Y. · Trans. Am. Soc. Artif. Intern. Organs · 1982 · 28 · 459
10. 10.1007/978-1-4613-2433-1_2610.1007/978-1-4613-2433-1_26 ↗
11. 10.1097/00002480-198609000-0002410.1097/00002480-198609000-00024 ↗
12. 10.1111/j.1749-6632.1977.tb41756.x10.1111/j.1749-6632.1977.tb41756.x ↗
13. 10.1172/JCI10967110.1172/JCI109671 ↗
14. Mori, Y., S. Nagaoka, H. Takiuchi, R. Terada, S. Nishiumi, H. Tanzawa, A. Kuwano and H. Miyama. Progress in Artificial Organs 1983. Cleveland: ISAO Press, p. 825 (1984).