DataVXJournal of Biomaterials ApplicationsPaper
journal article·2012-11

Sodium-phosphorylated chitosan/zinc oxide complexes and evaluation of their cytocompatibility: An approach for periodontal dressing

Veeranuch Srakaew, Praphansri Ruangsri, Kanyarat Suthin, Pasutha Thunyakitpisal, Wanpen Tachaboonyakiat

Journal of Biomaterials Applications· Volume 27· Issue 4
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Source abstract

Abstract

The aim of this study was to evaluate the possibility of metal complex formation between sodium-phosphorylated chitosan (PCTS) and ZnO. The polymer–metal complex formation was investigated in terms of thermal degradation. The structure deduction of the PCTS/ZnO complex was investigated by means of Fourier transform infrared spectroscopy and X-ray diffraction (XRD). The PCTS/ZnO complexes were formed by the sharing of lone pairs of electrons from the N atoms in the amine groups and O atoms in the phosphate and hydroxyl groups of PCTS to the protonated hydroxyl species on the ZnO surface. Because complex formation occurred at the surface of ZnO particles, it did not change the ZnO crystalline structure. Cytotoxicity, evaluated by a direct contact test with primary human gingival fibroblast cells, revealed that PCTS was biocompatible and reduced the cytotoxicity of ZnO by complexation, making PCTS/ZnO complexes potentially biocompatible. Within the limits of these data, it appears that PCTS could be used as a reaction rate-modifying agent in periodontal dressings.
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Research context

PolymersBiomaterials

OpenAlex topics: Polymer Surface Interaction Studies · Oral microbiology and periodontitis research · Advanced Drug Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science, Faculty of Science, Chulalongkorn University, Phyathai, Patumwan, Bangkok 10330, Thailand

Department of Conservative Dentistry, Faculty of Dentistry, Prince of Songkla University, P.O. Box 17, 15 Karnjanawanich Road, HatYai, Songkhla 90112, Thailand

Dental Sea Clinic, 39/3 Prabarami Road, Patong, Kathu, Phuket 83150, Thailand

Department of Anatomy, Dental Biomaterial Sciences Program, Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Rd, Patumwan, Bangkok 10330, Thailand

Unit Cell for Research and Development of Herbals and Natural Products for Dental Application, Faculty of Dentistry, Chulalongkorn University, Henri-Dunant Rd, Patumwan, Bangkok 10330, Thailand

Center for Petroleum, Petrochemicals and Advanced Materials, Chulalongkorn University, Bangkok 10330, Thailand

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