Decoding the Role of NEIL1 Gene in DNA Repair and Lifespan: A Literature Review with Bioinformatics Analysis
Source abstract
Abstract
Abstract Longevity, the length of an organism's lifespan, is impacted by environmental factors, metabolic processes, and genetic determinants. The base excision repair (BER) pathway is crucial for maintaining genomic integrity by repairing oxidatively modified base lesions. Nei‐like DNA Glycosylase 1 (NEIL1), part of the BER pathway, is vital in repairing oxidative bases in G‐rich DNA regions, such as telomeres and promoters. Hence, in this comprehensive review, it have undertaken a meticulous investigation of the intricate association between NEIL1 and longevity. The analysis delves into the multifaceted aspects of the NEIL1 gene, its various RNA transcripts, and the diverse protein isoforms. In addition, a combination of bioinformatic analysis is conducted to identify NEIL1 mutations, transcription factors, and epigenetic modifications, as well as its lncRNA/pseudogene/circRNA‐miRNA‐mRNA regulatory network. The findings suggest that the normal function of NEIL1 is a significant factor in human health and longevity, with defects in NEIL1 potentially leading to various cancers and related syndromes, Alzheimer's disease, obesity, and diabetes.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: RNA modifications and cancer · MicroRNA in disease regulation · RNA and protein synthesis mechanisms
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Medical Genetics Faculty of Medicine Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
Molecular Medicine Research Center Hormozgan Health Institute Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
Student Research Committee Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
Department of Medical Genetics School of Medicine Tehran University of Medical Sciences Tehran 1416634793 Iran
Student Research Committee Faculty of Para‐Medicine Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
School of Infection & Immunity College of Medical Veterinary & Life Sciences University of Glasgow Glasgow G12 8QQ UK
Department of Pharmaceutics Faculty of Pharmacy Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
USERN Office Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
Endocrinology and Metabolism Research Center Hormozgan University of Medical Sciences Bandar Abbas 7916613885 Iran
References (100+)
Show source-provided references
1. 10.3390/nu303027410.3390/nu3030274 ↗
2. 10.12688/f1000research.19610.110.12688/f1000research.19610.1 ↗
3. 10.1016/j.exger.2017.08.00510.1016/j.exger.2017.08.005 ↗
4. 10.1097/NEN.0b013e31816ff78010.1097/NEN.0b013e31816ff780 ↗
5. 10.3390/ijms2303149910.3390/ijms23031499 ↗
6. 10.1016/j.mad.2008.03.00110.1016/j.mad.2008.03.001 ↗
7. Ahmad H. I. · Oxid. Med. Cell Longev. · 2022 · 2022 · 1
8. 10.3233/JAD-2011-11028110.3233/JAD-2011-110281 ↗
9. 10.1038/s41598-017-04472-410.1038/s41598-017-04472-4 ↗
10. 10.1016/S0079-6603(01)68100-510.1016/S0079-6603(01)68100-5 ↗
11. 10.1074/jbc.C20035520010.1074/jbc.C200355200 ↗
12. 10.1016/j.mgene.2016.11.00610.1016/j.mgene.2016.11.006 ↗
13. 10.1073/pnas.130423111010.1073/pnas.1304231110 ↗
14. 10.1074/jbc.M90074620010.1074/jbc.M900746200 ↗
15. 10.1016/j.dnarep.2018.04.00110.1016/j.dnarep.2018.04.001 ↗
16. 10.1073/pnas.050744410310.1073/pnas.0507444103 ↗
17. 10.1073/pnas.120415610910.1073/pnas.1204156109 ↗
18. 10.1038/jcbfm.2010.14710.1038/jcbfm.2010.147 ↗
19. 10.1142/9789814719735_002010.1142/9789814719735_0020 ↗
20. 10.1093/carcin/bgh26710.1093/carcin/bgh267 ↗
21. 10.1093/nar/gkac24010.1093/nar/gkac240 ↗
22. 10.1002/pro.458210.1002/pro.4582 ↗
23. 10.1093/nar/gkn18810.1093/nar/gkn188 ↗
24. 10.1186/1748-7188-6-2610.1186/1748-7188-6-26 ↗
25. 10.1093/nar/gky114110.1093/nar/gky1141 ↗
26. 10.1006/jmbi.2000.404210.1006/jmbi.2000.4042 ↗
27. 10.1093/nar/gkt102310.1093/nar/gkt1023 ↗
28. 10.1093/nar/gky101010.1093/nar/gky1010 ↗
29. 10.1371/journal.pone.000342010.1371/journal.pone.0003420 ↗
30. 10.1093/nar/gkg59510.1093/nar/gkg595 ↗
31. 10.1155/2016/154639210.1155/2016/1546392 ↗
32. 10.1093/nar/gkz97210.1093/nar/gkz972 ↗
33. 10.1093/bioinformatics/bty89710.1093/bioinformatics/bty897 ↗
34. 10.3389/fgene.2020.57715210.3389/fgene.2020.577152 ↗
35. 10.1093/nar/gki03310.1093/nar/gki033 ↗
36. 10.1007/978-981-16-5812-9_210.1007/978-981-16-5812-9_2 ↗
37. 10.1002/cpbi.510.1002/cpbi.5 ↗
38. 10.1093/bioinformatics/bty89710.1093/bioinformatics/bty897 ↗
39. 10.1093/nar/gkz97210.1093/nar/gkz972 ↗
40. 10.3389/fonc.2022.87086310.3389/fonc.2022.870863 ↗
41. 10.1016/j.ajhg.2021.12.01010.1016/j.ajhg.2021.12.010 ↗
42. 10.3390/genes1103031410.3390/genes11030314 ↗
43. 10.1038/hdy.2010.210.1038/hdy.2010.2 ↗
44. 10.1093/nar/gkw102410.1093/nar/gkw1024 ↗
45. 10.1016/j.dnarep.2020.10293110.1016/j.dnarep.2020.102931 ↗
46. 10.3390/genes807017510.3390/genes8070175 ↗
47. 10.1038/onc.2011.66010.1038/onc.2011.660 ↗
48. 10.1101/gr.22910210.1101/gr.229102 ↗
49. 10.1093/nar/gkac107210.1093/nar/gkac1072 ↗
50. 10.1093/nar/gks117210.1093/nar/gks1172 ↗
51. 10.1093/nar/gku63110.1093/nar/gku631 ↗
52. 10.1093/bioinformatics/btw66010.1093/bioinformatics/btw660 ↗
53. 10.1093/nar/gkt118110.1093/nar/gkt1181 ↗
54. 10.1093/nar/gkq102710.1093/nar/gkq1027 ↗
55. 10.1093/nar/gkm95210.1093/nar/gkm952 ↗
56. 10.1093/nar/gkj11210.1093/nar/gkj112 ↗
57. 10.1093/nar/gkh02310.1093/nar/gkh023 ↗
58. R. Core Team R: A Language And Environment For Statistical Computing R Foundation for Statistical Computing Vienna Austria2022.
59. R. S. Team RStudio: Integrated Development Environment for R. RStudio PBC Boston MA2022
60. K. R.Zhou J. H.Huang S.Liu B.Li S. R.Liu W. J.Zheng L.Cai et al. An Encyclopedia of RNA Interactomes in ENCORI.
61. 10.1093/nar/gkt124810.1093/nar/gkt1248 ↗
62. 10.1101/gr.123930310.1101/gr.1239303 ↗
63. 10.1186/1752-0509-8-S4-S1110.1186/1752-0509-8-S4-S11 ↗
64. 10.1016/j.cell.2018.01.02910.1016/j.cell.2018.01.029 ↗
65. 10.1073/pnas.202117111810.1073/pnas.2021171118 ↗
66. 10.1093/nar/gkt63510.1093/nar/gkt635 ↗
67. 10.1093/database/baw10010.1093/database/baw100 ↗
68. 10.1093/bioinformatics/btq46610.1093/bioinformatics/btq466 ↗
69. 10.1093/nar/gkh01210.1093/nar/gkh012 ↗
70. 10.1093/nar/gkt99710.1093/nar/gkt997 ↗
71. 10.1093/database/bax02810.1093/database/bax028 ↗
72. 10.2147/CIA.S15851310.2147/CIA.S158513 ↗
73. 10.1016/j.biochi.2022.10.01410.1016/j.biochi.2022.10.014 ↗
74. Han D. · Elife · 2019 · 8
75. 10.1038/s41467-021-24431-y10.1038/s41467-021-24431-y ↗
76. 10.1016/S1568-7864(03)00025-910.1016/S1568-7864(03)00025-9 ↗
77. 10.1074/jbc.M30865820010.1074/jbc.M308658200 ↗
78. 10.1021/bi049097i10.1021/bi049097i ↗
79. 10.1016/j.dnarep.2004.07.00610.1016/j.dnarep.2004.07.006 ↗
80. 10.1021/bi800160s10.1021/bi800160s ↗
81. 10.1021/bi901852q10.1021/bi901852q ↗
82. 10.1021/bi048162l10.1021/bi048162l ↗
83. 10.1074/jbc.M40039320010.1074/jbc.M400393200 ↗
84. 10.1093/nar/gkm59210.1093/nar/gkm592 ↗
85. 10.1074/jbc.M113.47905510.1074/jbc.M113.479055 ↗
86. 10.1074/jbc.M80271220010.1074/jbc.M802712200 ↗
87. 10.1016/j.dnarep.2018.02.01210.1016/j.dnarep.2018.02.012 ↗
88. 10.1038/s41598-017-07458-410.1038/s41598-017-07458-4 ↗
89. 10.1371/journal.pone.002103910.1371/journal.pone.0021039 ↗
90. 10.1074/jbc.M115.69321810.1074/jbc.M115.693218 ↗
91. 10.1021/acs.biochem.0c0008010.1021/acs.biochem.0c00080 ↗
92. 10.1021/bi902161f10.1021/bi902161f ↗
93. 10.1016/j.dnarep.2012.09.00210.1016/j.dnarep.2012.09.002 ↗
94. 10.1093/gerona/glac21410.1093/gerona/glac214 ↗
95. 10.1016/j.canlet.2012.01.01610.1016/j.canlet.2012.01.016 ↗
96. 10.1016/j.gene.2015.06.04310.1016/j.gene.2015.06.043 ↗
97. 10.1016/j.dnarep.2009.03.00110.1016/j.dnarep.2009.03.001 ↗
98. 10.1016/j.dnarep.2019.03.00410.1016/j.dnarep.2019.03.004 ↗
99. 10.1073/pnas.162093211410.1073/pnas.1620932114 ↗
100. 10.1093/carcin/bgp11810.1093/carcin/bgp118 ↗