Curcumin-loaded chitosan nanoparticles promote diabetic wound healing via attenuating inflammation in a diabetic rat model

Diabetes caused wound healing delay is attributed to the enhanced and prolonged inflammation, which is always induced by a large amount of inflammatory mediators secreted by macrophage cells. Therefore, it is urgent to develop a strategy to attenuate macrophage cells-mediated inflammation in diabetic wound treatment. In this study, we fabricated curcumin-loaded chitosan nanoparticles (Cur-CS-NPs) and explored their potential to accelerate diabetic wound healing. The results showed the diabetic model treated by Cur-CS-NPs showed better physical characterizations than control group, manifested by a sustained drug release and efficient cell uptake. Furthermore, we found Cur-CS-NPs could effectively attenuate macrophage-mediated inflammation and enhanced angiogenesis in vitro and in vivo. Taken together, Cur-CS-NPs promote the diabetic wound healing in streptozotocin-induced diabetic rat models.