DataVXJournal of Biomaterials ApplicationsPaper
journal article·2005-10Open access

Repair of Bone Tissue Affected by Osteoporosis with Hydroxyapatite-Poly-L-lactide (HAp-PLLA) With and Without Blood Plasma

Z. Ajduković, S. Najman, Lj Ðorđević, V. Savić, D. Mihailović, D. Petrović, N. Ignjatović, D. Uskoković

Journal of Biomaterials Applications· Volume 20· Issue 2
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Source abstract

Abstract

The aim of this study is to examine the reparatory ability of the synthetic biomaterial hydroxyapatite-poly-L-lactide (HAp-PLLA), the replacement of alveolar ridge, and rehabilitation of bone defects caused by osteoporosis, in an experimental group of animals. The experiments are performed on syngeneic Sprague Dawley rats. Osteoporosis is induced by glucocorticoids in rats during a 12-week period. After this, the experimental group of animals is divided into five subgroups. An artificial defect is made in the alveolar bone on the left side of the mandible. In one group of animals, the defect is left to heal by itself, while in other groups, pure HAp-PLLA or one mixed with plasma is implanted. The best results are achieved by the implantation of the HAp-PLLA composite biomaterial mixed with autologous plasma. Formation of a new mandibular bone is seen, growing intensely, leading to rapid osteogenesis.
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Research context

BiomaterialsComposites

OpenAlex topics: Bone Tissue Engineering Materials · Facial Trauma and Fracture Management · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Medicine, Clinic of Stomatology, Department of Prosthodontics, Niš, Serbia and Montenegro

Faculty of Medicine, Institute of Biology, Niš, Serbia and Montenegro

Faculty of Medicine, Niš, Institute of Biochemical Research, Niš, Serbia and Montenegro

Faculty of Medicine, Institute of Pathology, Niš, Serbia and Montenegro

Faculty of Medicine, Clinic of Stomatology, Department of Maxillofacial Surgery, Niš, Serbia and Montenegro

Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, K. Mihailova 35/IV, 11000, Belgrade, Serbia and Montenegro

Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, K. Mihailova 35/IV, 11000, Belgrade, Serbia and Montenegro,

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