The Mechanical Behavior of Vascular Grafts: A Review
Source abstract
Abstract
The development of intimal hyperplasia (IH) near the anastomosis of a vascular graft to artery is directly related to changes in the wall shear rate distribution. Mismatch in compliance and diameter at the end-to-end anastomosis of a compliant artery and rigid graft cause shear rate disturbances that may induce intimal hyperplasia and ultimately graft failure. The principal strategy being developed to prevent IH is based on the design and fabrication of compliant synthetic or innovative tissue-engineered grafts with viscoelastic properties that mirror those of the human artery. The goal of this review is to discuss how mechanical properties including compliance mismatch, diameter mismatch, Young’s modulus and impedance phase angle affect graft failure due to intimal hyperplasia.
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Research context
OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Aortic Disease and Treatment Approaches · Coronary Interventions and Diagnostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
University Department of Surgery, The Royal Free Hospital, Pond Street, London NW3 2QG, U.K.
Vascular Haemodynamic Laboratory, University Department of Surgery, Royal Free and University College Medical School, University College London and The Royal Free Hospital, London NW3 2QG, UK
Cardio Tech International LTD., Cambrian House, Hawrd Road, Brymbo, Wrexham, LL11 5EA, UK
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