DataVXJournal of Biomaterials ApplicationsPaper
journal article·2020-05

Antibacterial activities and cell responses of Ti–Ag alloys with a hybrid micro- to nanostructured surface

Zeming Lei, Hangzhou Zhang, Erlin Zhang, Junhua You, Xiaoxue Ma, Xizhuang Bai

Journal of Biomaterials Applications· Volume 34· Issue 10
Publisher page
Source abstract

Abstract

In this study, the surfaces of Ti–Ag casting alloys were modified by chemical treatment (acid etching combined with alkaline treatment) to produce hybrid micron and submicron porosities, sponge-like nanostructures and Ag-containing particles. The surface characteristics, ion release, pH values, antibacterial activities and cell responses of the chemically treated Ti–Ag (Ti–Ag(CT)) samples were investigated. The antibacterial activities of the Ti–Ag(CT) samples were assessed using Staphylococcus aureus, and these samples showed strong antibacterial activities that were attributed to Ag ion release and Ag-containing particles. The effects of Ti–Ag(CT) samples on cells were assessed using MC3T3-E1 mouse preosteoblasts; samples with 1 and 3 wt.% Ag showed higher cell adhesion and higher alkaline phosphatase values than those of commercially available pure Ti samples. These results indicated that Ti–Ag casting alloys with 1 and 3 wt.% Ag modified by chemical treatment prevented bacterial infection and have latent capacities to promote osseointegration.
Source: crossref · Quality: baseline

Research context

Metals & alloysNanomaterials

OpenAlex topics: Bone Tissue Engineering Materials · Orthopaedic implants and arthroplasty · Titanium Alloys Microstructure and Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Hand Surgery Ward, Central Hospital Attached to Shenyang Medical College, Shenyang, China

Department of Orthopedics and Sports Medicine and Joint Surgery, The People's Hospital of China Medical University, Shenyang, China

Department of Orthopedics and Sports Medicine and Joint Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China

Key Laboratory for Anisotropy and Texture of Materials (ATM), Education Ministry of China, School of Material Science and Engineering, Northeastern University, Shenyang, China

School of Materials Science and Engineering, Shenyang University of Technology, Shenyang, China

Department of Medical Microbiology and Parasitology, College of Basic Medical Sciences, China Medical University, Shenyang, China

Funding

Special Research Foundation of the Health and Family Planning Commission of Liaoning Province · Science and Technology Project of Shenyang City · National Natural Science Foundation of China

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