Acrylic Copolymers as Candidates for Drug-Eluting Coating of Vascular Stents
Source abstract
Abstract
The aim of the present work is the synthesis and characterization of polymer materials showing good adhesion, drug loading, and delivery properties, for potential cardiovascular application. In particular, poly(methylmethacrylate-co-acrylic acid) copolymers are prepared in different compositions by a radical polymerization and investigated as potential materials to coat metallic stents and to carry out a local drug release. Films obtained by dissolving the copolymer in an appropriate organic solvent (also loaded with an anti-restenosis drug, such as tacrolimus) are investigated: physicochemical properties, adhesiveness to metallic stent material, and kinetics of drug release in physiological environment are studied.
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Research context
OpenAlex topics: Coronary Interventions and Diagnostics · Peripheral Artery Disease Management · Antiplatelet Therapy and Cardiovascular Diseases
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy, , Interdepartmental Centre for the study and evaluation of Biomaterials and Endo-prosthesis'Nicolino Marchetti' (C.I.B.E.), Pisa, Italy
CNR Institute for Composite and Biomedical Materials IMCB Pisa, c/o Department of Chemical Engineering, Italy
Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy
Department of Mechanics, Politecnico in Turin, Italy
Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Italy, CNR Institute for Composite and Biomedical Materials IMCB Pisa, c/o Department of Chemical Engineering, Italy, Interdepartmental Centre for the study and evaluation of Biomaterials and Endo-prosthesis
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