DataVXJournal of Bioactive and Compatible PolymersPaper
journal article·2007-05

pH-Sensitive IPN Hydrogel Beads of Carrageenan-Alginate for Controlled Drug Delivery

Z. Mohamadnia, M.J. Zohuriaan-Mehr, K. Kabiri, A. Jamshidi, H. Mobedi

Journal of Bioactive and Compatible Polymers· Volume 22· Issue 3
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Source abstract

Abstract

Interpenetrating polymer network (IPN) hydrogel beads of carrageenan-sodium alginate (Caralgi) were prepared under mild conditions. Betamethasone acetate, as a water-soluble drug model, was simultaneously loaded while the hydrogel network was being formed. The effect of pH and temperature of the preparative media on the drug loading efficiency was investigated. Maximum loading efficiency (71%) was achieved at pH 4.8 and 55°C. The chemical structure and morphology of the Caralgi IPN hydrogels with and without drug were studied using FTIR and SEM analyses. The system exhibited a loading efficiency that depended on the pH and temperature. The in vitro release behavior by Caralgi IPN samples, prepared under various conditions, was evaluated and compared with that of the non-IPN alginate-Ca 2+ and carrageenan-K + hydrogels at pH 1.2 and 7.4.
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Research context

Polymers

OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Drug Delivery Systems · Polysaccharides Composition and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Novel Drug Delivery Systems, Faculty of Polymer Science, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran, Department of Color, Resins and Surface Coatings, Faculty of Polymer Processing, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran

Department of Color, Resins and Surface Coatings, Faculty of Polymer Processing, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran, ,

Department of Color, Resins and Surface Coatings, Faculty of Polymer Processing, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran

Department of Novel Drug Delivery Systems, Faculty of Polymer Science, Iran Polymer and Petrochemical Institute (IPPI), P.O. Box 14965-115, Tehran, Iran

References (15)

Show source-provided references
1. 10.1177/088391150404160710.1177/0883911504041607 ↗
2. 10.3109/0265204030917806010.3109/02652040309178060 ↗
3. Bajpai, S.K. · Polym. · 2004 · 59 · 129
4. Whistler, R.L. and Bemiller, J.N. (eds). (1973). Industrial Gums, 2nd edn, pp. 49—114, Academic Press, New York.
5. 10.1016/S0378-5173(01)00814-610.1016/S0378-5173(01)00814-6 ↗
6. 10.1016/S0169-409X(01)00203-410.1016/S0169-409X(01)00203-4 ↗
7. 10.1002/app.2195710.1002/app.21957 ↗
8. 10.1002/app.2276010.1002/app.22760 ↗
9. Mohamadnia, Z. · Sci, Polym. · 2006
10. 10.1006/fstl.2002.092810.1006/fstl.2002.0928 ↗
11. 10.1002/mabi.20050006310.1002/mabi.200500063 ↗
12. United States Pharmacopial Convention, Inc., USP 25 (2002). Physical Tests, @#x3C; 711 > dissolution.
13. 10.1021/ie00100a01010.1021/ie00100a010 ↗
14. 10.1163/156856204245971510.1163/1568562042459715 ↗
15. Serp, D., Mueller, M., Stockar, U.V., and Marison, I.W. (2002). Low-Temprature Electron Microscopy for the Study of Polysaccharide Ultrastructures in Hydrogels. II. Effect of Temperature on the Structure of Ca2+-Alginate Beads, Biotechnol. Bioeng. 79: 253—259.10.1002/bit.10287 ↗