Soluble Polymeric Carriers for Drug Delivery: Part 5: Solution Properties and Biodistribution Behaviour of N-(2-Hydroxypropyl)Methacrylamide-co-N-(2-[4-Hydroxyphenyl]Ethyl) Acrylamide Copolymer Substituted with Cholesterol

Lusie E. Ambler; Laurence Brookman; Janet Brown; Peter Goddard; Karel Petrak

doi:10.1177/088391159200700301

journal article·1992-07

Soluble Polymeric Carriers for Drug Delivery: Part 5: Solution Properties and Biodistribution Behaviour of N-(2-Hydroxypropyl)Methacrylamide-co-N-(2-[4-Hydroxyphenyl]Ethyl) Acrylamide Copolymer Substituted with Cholesterol

Lusie E. Ambler, Laurence Brookman, Janet Brown, Peter Goddard, Karel Petrak

Journal of Bioactive and Compatible Polymers· Volume 7· Issue 3

Publisher page

Source abstract

Abstract

A copolymer of N-(2-hydroxypropyl)methacrylamide (HPMA) and N-(2-[4-hydroxyphenyl]ethyl)acrylamide (HPEA) was derivatized with 2-4 mole% of N-(2-[(cholest-5-en-3-yl(3β)oxycarbonyl)oxypropyl]methacrylamide residues (cholesteryl residues). The effect of polymer modification on some of its solution properties, and on its behaviour in vivo in experimental animals, has been examined.

Source: crossref · Quality: baseline

Research context

Polymers

OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Polymer Synthesis and Characterization · Advanced Drug Delivery Systems

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Advanced Drug Delivery Research Unit CIBA-GEIGY Pharmaceuticals Wimblehurst Road Horsham, West Sussex, RH12 4AB United Kingdom

References (24)

Show source-provided references

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