A Microfluidic Model of AQP4 Polarization Dynamics and Fluid Transport in the Healthy and Inflamed Human Brain: The First Step Towards Glymphatics‐on‐a‐Chip (Adv. Biology 12/2022)

Steps Towards Glymphatics-on-a-Chip In article 2200027, Lee and co-workers establish a microfluidic model of the gliovascular unit (GVU) comprised of human astrocytes and a bioengineered blood vessel. They demonstrate that chronic neuroinflammation impairs the drainage of fluid and amyloid-β(1-40) tracer through matrisome-dependent and cell-dependent pathways in GVU-on-a-chip. They also show that inflamed chips exhibit evidence of AQP4 depolarization.