Macromolecular Prodrugs of 5-Fluorouracil. 1: Synthesis and Hydrolytic Stability
Source abstract
Abstract
The hydroxyl groups of poly(ethylene glycol), dextran and poly-[N 5 -(2-hydroxy-ethyl-L-glutamineI were activated using the 4-nitrophenyl chloroformate method. The resulting phenyl carbonate groups reacted quantitatively with the primary amine groups of oligopeptides with 2-(5-fluorouracil-1-yl) glycine ethyl ester moiety as C-terminus. Following this procedure, 5-fluorouracil-polymer conjugates with peptide chains of different amino acid sequences and configurations were synthesized. The conjugates showed a good hydrolytic stability in buffer solutions of pH 7.4 and 5.5, as well as in calf serum, which indicated good stability of the polymer-drug linkage in the blood.
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Research context
OpenAlex topics: Colorectal Cancer Treatments and Studies · Cancer therapeutics and mechanisms · Peptidase Inhibition and Analysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Organic Chemistry, Biomaterial & Polymer Research Group, University of Gent, Krijgslaan 281 S4 bis, 9000 Gent, Belgium
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