New Thermo-responsive Hydrogels Based on Poly (N-isopropylacrylamide)/ Hyaluronic Acid Semi-interpenetrated Polymer Networks: Swelling Properties and Drug Release Studies
Source abstract
Abstract
New pH and temperature sensitive semi-interpenetrated polymer networks (semi-IPNs) were developed by combining cross-linked PNIPAAm with hyaluronic acid (HA). At pH 7.4, the PNIPAAm/HA semi-IPN hydrogels had significantly greater and faster swelling at 25°C and a more complete deswelling at 37°C than PNIPAAm hydrogels. The temperature-dependent reversibility behavior was analyzed for biomaterial applications. Gentamicin was incorporated as a model drug, and the release profile from the hydrogels was followed under physiological conditions. The presence of HA, even in small quantities, allowed a more complete release of the gentamicin from the hydrogel. The PNIPAAm/HA semi-IPN hydrogels respond to both changes in temperature and pH making it suitable as a delivery system for therapeutics.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Hydrogels: synthesis, properties, applications · 3D Printing in Biomedical Research · Advanced Materials and Mechanics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
3B's Research Group - Biomaterials, Biodegradables and Biomimetics AvePark, Zona Industrial da Gandra, S. Cláudio do Barco 4806-909 Caldas das Taipas - Guimarães, Portugal, IBB - Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Guimarães, Portugal
3B's Research Group - Biomaterials, Biodegradables and Biomimetics AvePark, Zona Industrial da Gandra, S. Cláudio do Barco 4806-909 Caldas das Taipas - Guimarães, Portugal, IBB - Institute for Biotechnology and Bioengineering PT Government Associated Laboratory, Guimarães, Portugal,
References (46)
Show source-provided references
1. 10.1002/adem.20070035510.1002/adem.200700355 ↗
2. Gupta, P. · Research focus · 2002 · 7 · 569
3. 10.1016/j.addr.2006.09.02010.1016/j.addr.2006.09.020 ↗
4. 10.1177/088391150910447510.1177/0883911509104475 ↗
5. 10.1016/S0169-409X(01)00203-410.1016/S0169-409X(01)00203-4 ↗
6. 10.1016/S0167-7799(99)01345-110.1016/S0167-7799(99)01345-1 ↗
7. 10.1002/adma.20050161210.1002/adma.200501612 ↗
8. 10.1016/S0167-7799(02)01962-510.1016/S0167-7799(02)01962-5 ↗
9. 10.1039/B406727D10.1039/B406727D ↗
10. 10.1039/b714376a10.1039/b714376a ↗
11. 10.1016/j.ejpb.2004.03.01910.1016/j.ejpb.2004.03.019 ↗
12. 10.1016/S0142-9612(01)00127-210.1016/S0142-9612(01)00127-2 ↗
13. 10.1016/j.biomaterials.2004.01.05110.1016/j.biomaterials.2004.01.051 ↗
14. 10.1021/bm701390f10.1021/bm701390f ↗
15. Rzaev, Z.M.O. · Polym. Sci. · 2007 · 32 · 534
16. Shi, J. · Biosci. · 2006 · 6 · 358
17. 10.1016/j.jconrel.2004.04.01410.1016/j.jconrel.2004.04.014 ↗
18. Wu, J.Y. · Int. Symp. Control Release Bioact. Mater. · 2003 · 30 · 696
19. 10.1016/S0378-5173(01)00976-010.1016/S0378-5173(01)00976-0 ↗
20. 10.1038/374240a010.1038/374240a0 ↗
21. 10.1021/bm060543m10.1021/bm060543m ↗
22. 10.1016/0168-3659(94)90229-110.1016/0168-3659(94)90229-1 ↗
23. 10.1163/156856294X0053610.1163/156856294X00536 ↗
24. 10.1016/S0169-409X(01)00243-510.1016/S0169-409X(01)00243-5 ↗
25. 10.1016/j.jconrel.2005.10.01310.1016/j.jconrel.2005.10.013 ↗
26. Chaterji, S. · Polym. Sci. · 2007 · 32 · 1083
27. 10.1016/j.jconrel.2004.10.02110.1016/j.jconrel.2004.10.021 ↗
28. 10.1002/marc.20070077810.1002/marc.200700778 ↗
29. 10.1016/j.jconrel.2005.10.01310.1016/j.jconrel.2005.10.013 ↗
30. 10.1016/0168-3659(92)90212-A10.1016/0168-3659(92)90212-A ↗
31. 10.1098/rsif.2007.022010.1098/rsif.2007.0220 ↗
32. 10.1089/ten.2006.12.213110.1089/ten.2006.12.2131 ↗
33. Wei, Z. · Chem. · 2006 · 18 · 1684
34. 10.4161/org.615210.4161/org.6152 ↗
35. 10.1016/j.matbio.2006.08.26110.1016/j.matbio.2006.08.261 ↗
36. 10.1002/term.6110.1002/term.61 ↗
37. 10.1002/(SICI)1097-4636(20000615)50:4<574::AID-JBM13>3.0.CO;2-I10.1002/(SICI)1097-4636(20000615)50:4<574::AID-JBM13>3.0.CO;2-I ↗
38. 10.2353/ajpath.2006.06020610.2353/ajpath.2006.060206 ↗
39. 10.1016/j.biomaterials.2005.09.03510.1016/j.biomaterials.2005.09.035 ↗
40. 10.1016/S0378-5173(00)00520-210.1016/S0378-5173(00)00520-2 ↗
41. 10.1039/B603930H10.1039/B603930H ↗
42. 10.1002/jbm.b.3090710.1002/jbm.b.30907 ↗
43. 10.1002/mabi.20070017710.1002/mabi.200700177 ↗
44. 10.1002/adma.20060181710.1002/adma.200601817 ↗
45. 10.1016/j.carres.2007.07.00710.1016/j.carres.2007.07.007 ↗
46. 10.1016/j.actbio.2008.06.01210.1016/j.actbio.2008.06.012 ↗