Mineralization of porous hydrogels based on semi-interpenetrated networks of poly[2-ethyl(2-pyrrolidone) methacrylate] and hyaluronic acid in simulated body fluid
Source abstract
Abstract
Poly[2-ethyl(2-pyrrolidone) methacrylate] and hyaluronic acid hydrogels were synthesized via free-radical polymerization of 2-ethyl(2-pyrrolidone) methacrylate, hyaluronic acid and different crosslinkers. The ability of these hydrogels to induce apatite formation by incubating in simulated body fluid was investigated. The effect of hyaluronic acid content, crosslinkers and immersion time on mineralization behaviour and interface properties as well as the metabolic activity of different cultured cells were also determined. The bioactivity of the poly[2-ethyl(2-pyrrolidone) methacrylate] and hyaluronic acid hydrogels along with cell viability data indicated their potential application in bone tissue engineering.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Hydrogels: synthesis, properties, applications · 3D Printing in Biomedical Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Rheumatology Division, CIBER–BBN/ISCIII, Tissue Engineering and Cellular Therapy Group (CBTTC-CHUAC), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain
Centre for Biomaterials and Tissue Engineering, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
Biomaterials Department, Institute of Polymer Science and Technology, CSIC and CIBER–BBN, Madrid, Spain
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