A Convenient Method for the Synthesis of (S)-Dolichol and (S)-Nordolichol
Source abstract
Abstract
A procedure for the preparation of (S)-dolichol and (S)-nor-dolichol starting from the polyprenyl fraction extracted from Gingko Biloba integer or extracted leaves is described. Two chiral isoprenoid compounds in good yields and high degree of enantiomeric excess were obtained. The (S)-nordolichol appears to be a good chiral precursor for the preparation of 14 C-labeled (S)-dolichol which is to be used in investigations aimed at gaining further information with respect to the role of dolichol in the function of living cells.
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Research context
OpenAlex topics: Plant biochemistry and biosynthesis · Enzyme Catalysis and Immobilization · Coenzyme Q10 studies and effects
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry and Industrial Chemistry UdR of the Consortium INSTM University of Pisa via Risorgimento 35, 56123–Pisa, Italy
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