Preparation and properties of N -glycosylated chitosan/polyvinyl alcohol hydrogels for use in wound dressings
Source abstract
Abstract
Chitosan and its derivatives show potent biocompatibility, biodegradability, antimicrobial activity, hemostatic effects, and wound healing properties. Their application in wound dressings has garnered substantial research interest. In this work, we prepared a drug-loaded hydrogel by mixing N-glycosylated chitosan with polyvinyl alcohol (PVA), followed by loading of ofloxacin. A 2:1 volume ratio of chitosan to PVA was found to be optimal based on swelling and water evaporation rates. The slow-drug-release performance of the blended hydrogel was best when the ofloxacin loading was 5.0%. The ofloxacin-loaded hydrogel shows excellent antimicrobial properties in vitro and wound healing ability in an in vivo rabbit full-thickness excision wound model. The chitosan/PVA blended hydrogel has great potential for use in wound dressings and sustained drug release.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Hydrogels: synthesis, properties, applications · Electrospun Nanofibers in Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China
Funding
Zhejiang Foundation Public Welfare Research Project
References (18)
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