Bioactive oligopeptides and the application in skin regeneration and rejuvenation
Source abstract
Abstract
Oligopeptides, composed of 2–10 amino acid residues, are protein fragments with unique structural characteristics, including small molecular size, high biocompatibility, and modifiable functional groups. These features endow oligopeptides with excellent permeability, safety, and versatile biological activities, making them widely applicable in disease treatment, drug delivery, and skincare. In particular, oligopeptides have emerged as advanced ingredients in skincare, offering anti-aging, anti-wrinkle, and whitening effects by regulating key biological processes such as collagen synthesis, antioxidant defense, and melanin production. This review comprehensively discusses the structural properties, functional mechanisms, and diverse applications of oligopeptides and their derivatives, highlighting their potential in skin regeneration, rejuvenation, and anti-aging medicine. By providing insights into the latest advancements, this review aims to serve as a valuable reference for future research and development in oligopeptide-based therapeutics and skincare innovations.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Protein Hydrolysis and Bioactive Peptides · Skin Protection and Aging · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Hangzhou Singclean Medical Products Co., Ltd, Hangzhou, China
Department of Burns and Wound Care Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Department of Plastic and Cosmetic, Tongde Hospital of Zhejiang Province, Hangzhou, China
Department of Plastic and Cosmetic, Zhejiang Hospital, Hangzhou, China
Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China
Funding
Zhejiang Province Traditional Chinese Medicine Science and technology Project · medical and health research project of zhejiang province
References (100+)
Show source-provided references
1. 10.1016/j.jphotobiol.2016.09.03810.1016/j.jphotobiol.2016.09.038 ↗
2. 10.1080/14712598.2019.165259210.1080/14712598.2019.1652592 ↗
3. 10.1034/j.1600-0625.2000.009003165.x10.1034/j.1600-0625.2000.009003165.x ↗
4. 10.1111/j.1529-8019.2007.00148.x10.1111/j.1529-8019.2007.00148.x ↗
5. 10.1002/jps.2119810.1002/jps.21198 ↗
6. 10.3390/ph1408070210.3390/ph14080702 ↗
7. 10.1111/j.1468-2494.2009.00490.x10.1111/j.1468-2494.2009.00490.x ↗
8. 10.1111/j.1473-2165.2009.00416.x10.1111/j.1473-2165.2009.00416.x ↗
9. 10.3390/cosmetics402001610.3390/cosmetics4020016 ↗
10. 10.1111/jocd.1317610.1111/jocd.13176 ↗
11. 10.1111/jdv.1353010.1111/jdv.13530 ↗
12. 10.1021/acs.jafc.5b0102610.1021/acs.jafc.5b01026 ↗
13. 10.1016/j.critrevonc.2003.06.00710.1016/j.critrevonc.2003.06.007 ↗
14. 10.1002/psc.245510.1002/psc.2455 ↗
15. 10.1016/0014-5793(88)80509-X10.1016/0014-5793(88)80509-X ↗
16. 10.1016/0024-3205(92)90504-I10.1016/0024-3205(92)90504-I ↗
17. 10.1089/pho.2007.206210.1089/pho.2007.2062 ↗
18. 10.1172/JCI11684210.1172/JCI116842 ↗
19. 10.1111/jocd.1231310.1111/jocd.12313 ↗
20. 10.1001/archfaci.7.1.2710.1001/archfaci.7.1.27 ↗
21. 10.1007/s00403-009-0942-x10.1007/s00403-009-0942-x ↗
22. 10.1002/psc.333910.1002/psc.3339 ↗
23. 10.1002/psc.323410.1002/psc.3234 ↗
24. 10.1038/s41598-019-57159-310.1038/s41598-019-57159-3 ↗
25. 10.1111/j.1468-2494.2008.00429.x10.1111/j.1468-2494.2008.00429.x ↗
26. 10.1021/ci500370x10.1021/ci500370x ↗
27. 10.1016/j.bmcl.2004.03.04610.1016/j.bmcl.2004.03.046 ↗
28. Park DH, Jung DH, Kim SJ, et al.Galloyl-RGD as a new cosmetic ingredient. 2014.
29. 10.1007/s10989-017-9648-710.1007/s10989-017-9648-7 ↗
30. 10.1111/j.1600-0625.2011.01307.x10.1111/j.1600-0625.2011.01307.x ↗
31. 10.1111/bjd.1763410.1111/bjd.17634 ↗
32. 10.1002/jor.2045510.1002/jor.20455 ↗
33. 10.1021/mp300549d10.1021/mp300549d ↗
34. 10.3390/molecules2420369810.3390/molecules24203698 ↗
35. 10.1111/j.1467-2494.2005.00261.x10.1111/j.1467-2494.2005.00261.x ↗
36. 10.1007/s13770-016-0017-y10.1007/s13770-016-0017-y ↗
37. 10.1016/j.ejmech.2013.09.01110.1016/j.ejmech.2013.09.011 ↗
38. 10.1016/j.bmcl.2008.10.11210.1016/j.bmcl.2008.10.112 ↗
39. 10.1089/ten.tea.2017.006010.1089/ten.tea.2017.0060 ↗
40. 10.3390/ijms2024614310.3390/ijms20246143 ↗
41. 10.1016/j.foodchem.2020.12804710.1016/j.foodchem.2020.128047 ↗
42. 10.1046/j.1467-2494.2002.00153.x10.1046/j.1467-2494.2002.00153.x ↗
43. 10.3109/14764172.2013.76927310.3109/14764172.2013.769273 ↗
44. 10.1007/s40257-013-0009-910.1007/s40257-013-0009-9 ↗
45. 10.1016/j.redox.2015.04.01010.1016/j.redox.2015.04.010 ↗
46. 10.3109/1541906950908101310.3109/15419069509081013 ↗
47. 10.1007/s00403005022710.1007/s004030050227 ↗
48. 10.1016/j.jdermsci.2015.10.00110.1016/j.jdermsci.2015.10.001 ↗
49. 10.1007/s10811-017-1378-x10.1007/s10811-017-1378-x ↗
50. Mondon P, Hillion M, Peschard O, et al. Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption ionization mass spectrometric imaging. 2015.
51. 10.1002/ardp.20210020410.1002/ardp.202100204 ↗
52. 10.3390/md1709052010.3390/md17090520 ↗
53. 10.1016/j.ejpb.2016.06.01410.1016/j.ejpb.2016.06.014 ↗
54. 10.3390/ph1506068410.3390/ph15060684 ↗
55. 10.1016/j.foodchem.2013.09.13610.1016/j.foodchem.2013.09.136 ↗
56. 10.1038/jid.2009.12410.1038/jid.2009.124 ↗
57. 10.3109/14764172.2012.67274510.3109/14764172.2012.672745 ↗
58. 10.1016/j.jbiosc.2015.10.01010.1016/j.jbiosc.2015.10.010 ↗
59. 10.1002/cmdc.20150047210.1002/cmdc.201500472 ↗
60. 10.1002/cbin.1101810.1002/cbin.11018 ↗
61. 10.1080/09168451.2019.158055910.1080/09168451.2019.1580559 ↗
62. 10.3389/fmed.2020.60890310.3389/fmed.2020.608903 ↗
63. GHK–Copper peptide in skin remodeling and anti-aging. 2010.
64. 10.3390/ijms1907198710.3390/ijms19071987 ↗
65. 10.1155/2015/64810810.1155/2015/648108 ↗
66. 10.1163/15685620878490943510.1163/156856208784909435 ↗
67. 10.1155/2012/32483210.1155/2012/324832 ↗
68. Li H, Low YS, Chong HP, et al. Microneedle-mediated delivery of copper peptide through skin. Pharm Res 2015; 32(8): 2678–2689.
69. 10.1016/j.clindermatol.2010.03.02310.1016/j.clindermatol.2010.03.023 ↗
70. 10.1038/srep3766410.1038/srep37664 ↗
71. 10.3390/ijms2117619010.3390/ijms21176190 ↗
72. 10.1016/S0024-3205(00)00803-110.1016/S0024-3205(00)00803-1 ↗
73. 10.1016/S0304-4165(01)00127-110.1016/S0304-4165(01)00127-1 ↗
74. 10.1021/bi00243a00910.1021/bi00243a009 ↗
75. 10.1016/S0021-9258(18)82153-610.1016/S0021-9258(18)82153-6 ↗
76. 10.1016/j.jchromb.2012.08.01010.1016/j.jchromb.2012.08.010 ↗
77. 10.1016/j.jpba.2020.11377510.1016/j.jpba.2020.113775 ↗
78. 10.1039/c0cc03793a10.1039/c0cc03793a ↗
79. 10.1021/la302123h10.1021/la302123h ↗
80. 10.1016/j.bmcl.2014.11.02110.1016/j.bmcl.2014.11.021 ↗
81. Kaczvinsky JR, Griffiths CEM, Schnicker MS, et al. Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging. 2009.
82. 10.1111/j.1468-2494.2011.00657.x10.1111/j.1468-2494.2011.00657.x ↗
83. Johnson EA. Clostridial toxins as therapeutic agents: bene¢ts of nature’s most toxic proteins. 1999.
84. 10.1038/3505201710.1038/35052017 ↗
85. 10.1590/S1984-8250201500040001610.1590/S1984-82502015000400016 ↗
86. Palmieri B, Noviello A, Corazzari V, et al. Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide-8. Clin Ter 2020; 171(6): e539–e548.
87. 10.1016/j.ejps.2014.12.00610.1016/j.ejps.2014.12.006 ↗
88. Lim SH, Sun Y, Thiruvallur Madanagopal T, et al. Enhanced skin permeation of anti-wrinkle peptides via molecular modification. Sci Rep 2018; 8(1): 1596.
89. 10.1088/1758-5090/ab6d3710.1088/1758-5090/ab6d37 ↗
90. 10.1016/j.jconrel.2020.10.02110.1016/j.jconrel.2020.10.021 ↗
91. Hantash BM, Jimenez F. A split-face, double-blind, randomized and placebo-controlled pilot evaluation of a novel oligopeptide for the treatment of recalcitrant melasma. J Drugs Dermatol 2009; 8(8): 732–735.
92. 10.1016/j.arthro.2015.10.01210.1016/j.arthro.2015.10.012 ↗
93. Senior RM, Griffin GL, Mecham DS, et al. VaI-Gly-VaI-Ala-pro-gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J Cell Biol 1984; 99(3): 870– 874.
94. 10.1016/j.freeradbiomed.2004.04.03310.1016/j.freeradbiomed.2004.04.033 ↗
95. 10.1128/MCB.00753-0710.1128/MCB.00753-07 ↗
96. 10.1111/jocd.1231410.1111/jocd.12314 ↗
97. 10.1159/00051449610.1159/000514496 ↗
98. 10.1111/j.1473-2165.2010.00494.x10.1111/j.1473-2165.2010.00494.x ↗
99. 10.1111/jocd.1217410.1111/jocd.12174 ↗
100. 10.1159/00035552310.1159/000355523 ↗