DataVXJournal of Applied Biomaterials & Functional MaterialsPaper
journal article·2024-01Open access

Application of Aleppo pine extract for skin burn treatment

Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah

Journal of Applied Biomaterials & Functional Materials· Volume 22
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Source abstract

Abstract

Objective: To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns. Methods: Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts’ healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation. Results: In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns. Conclusion: This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.
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Research context

OpenAlex topics: Wound Healing and Treatments · Burn Injury Management and Outcomes · Silymarin and Mushroom Poisoning

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Pharmacoepidemiology and Pharmacoeconomics Research Team, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco

Laboratory of Analytical Chemistry and Bromatology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco

Laboratory of Biodiversity, Ecology and genome, Faculty of Sciences, Mohammed V University, Rabat, Morocco

Laboratory of Anatomy Cytology, Faculty of Medicine and Pharmacy, Children’s Hospital, Mohammed V University in Rabat, Rabat, Morocco

Laboratory of Plant, Animal and Agro Industry Productions, Faculty of Sciences B.P. 133, Ibn Tofail University, Kenitra, Morocco

Department of Drug Sciences, Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco

Medicinal Aromatic and Poisonous Plants Research Center, College of Pharmacy King Saud University Riyadh Saudi Arabia

Department of Basic Science, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Laboratory of Human Pathologies Biology, Faculty of Sciences, Department of Biology, Mohammed V University in Rabat, Morocco

School of Pharmacy, KPJ Healthcare University, Nilai, Malaysia

School of Medical and Life Sciences, Sunway University, Bandar Sunway, Malaysia

Biopharmaceutical and Toxicological Analysis Research Team, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco

Funding

Princess Nourah bint Abdulrahman University Researchers Supporting Project

References (44)

Show source-provided references
1. 10.1128/CMR.19.2.403-434.200610.1128/CMR.19.2.403-434.2006 ↗
2. Dunne JA · Surgery · 2014 · 32 · 477
3. 10.1097/01.JPN.0000311871.46075.3d10.1097/01.JPN.0000311871.46075.3d ↗
4. Munteanu A · J Med Life · 2016 · 9 · 306
5. Barku VYA · Asian J Plant Sci Res · 2013 · 3 · 69
6. Chafiki N · Ann Burn Fire Disasters · 2007 · 20 · 13
7. Kanitakis J. · Eur J Dermatol · 2002 · 12 · 390
8. 10.1097/00004630-199603000-0000310.1097/00004630-199603000-00003 ↗
9. 10.1016/j.burns.2006.03.02310.1016/j.burns.2006.03.023 ↗
10. 10.1016/j.jss.2005.08.02510.1016/j.jss.2005.08.025 ↗
11. 10.1097/TA.000000000000083810.1097/TA.0000000000000838 ↗
12. Ozioma EOJ · Herb Med · 2019 · 10 · 191
13. World Health Organization. Principes méthodologiques généraux pour la recherche et l’évaluation relatives à la médecine traditionnelle, Organisation mondiale de la Santé, 2000.
14. 10.1186/1746-4269-7-910.1186/1746-4269-7-9 ↗
15. 10.1016/j.sjbs.2020.06.02010.1016/j.sjbs.2020.06.020 ↗
16. 10.1111/jocd.1423710.1111/jocd.14237 ↗
17. 10.1016/j.phymed.2017.09.00710.1016/j.phymed.2017.09.007 ↗
18. Chohra D · Acta Sci Nat · 2019 · 6 · 40
19. 10.1016/j.hermed.2019.10026210.1016/j.hermed.2019.100262 ↗
20. Nazim B · Curr Perspect Med Aromat Plants · 2020 · 3 · 18
21. 10.1016/j.ymeth.2007.01.00610.1016/j.ymeth.2007.01.006 ↗
22. 10.1097/00005373-196811000-0000610.1097/00005373-196811000-00006 ↗
23. 10.1097/BCR.0B013E318031A13F10.1097/BCR.0B013E318031A13F ↗
24. 10.1002/1096-9101(2000)27:1<39::AID-LSM5>3.0.CO;2-410.1002/1096-9101(2000)27:1<39::AID-LSM5>3.0.CO;2-4 ↗
25. Burns JF · Aus Indig Health Rev · 2013 · 13 · 1
26. 10.1016/0007-1226(87)90123-810.1016/0007-1226(87)90123-8 ↗
27. Marmouzi I · J Saudi Soc Agric Sci · 2018 · 17 · 229
28. 10.1016/j.sajb.2018.10.03810.1016/j.sajb.2018.10.038 ↗
29. 10.4103/1995-7645.25493710.4103/1995-7645.254937 ↗
30. 10.3390/ijerph1603049610.3390/ijerph16030496 ↗
31. 10.5455/javar.2019.f33310.5455/javar.2019.f333 ↗
32. 10.1111/j.1541-4337.2010.00131.x10.1111/j.1541-4337.2010.00131.x ↗
33. 10.14233/ajchem.2019.2163310.14233/ajchem.2019.21633 ↗
34. 10.1016/S0305-4179(03)00198-010.1016/S0305-4179(03)00198-0 ↗
35. 10.29252/ibj.24.2.9910.29252/ibj.24.2.99 ↗
36. 10.1016/j.burns.2018.03.00410.1016/j.burns.2018.03.004 ↗
37. 10.1111/iep.1234610.1111/iep.12346 ↗
38. 10.1155/2019/268410810.1155/2019/2684108 ↗
39. 10.1016/j.burns.2014.04.00110.1016/j.burns.2014.04.001 ↗
40. 10.3390/ijms1901007010.3390/ijms19010070 ↗
41. 10.12968/jowc.2008.17.3.2867010.12968/jowc.2008.17.3.28670 ↗
42. 10.1016/j.jep.2010.12.04210.1016/j.jep.2010.12.042 ↗
43. Kotian S · Ethiop J Health Sci · 2018 · 28 · 759
44. Busuioc CJ · Rom J Morphol Embryol · 2011 · 52 · 887