Influence of Albumin on Mineralization of PMMA-Based/Glass Composites
Source abstract
Abstract
Purpose The formation of a calcium phosphate layer on the surface of bone tissue engineering biomaterials is crucial for their integration in bone. Simulated biological fluids used to study the in vitro formation of those layers do not usually contain important organic components present in vivo–-notably proteins. In this work the influence of bovine serum albumin on the mineralization process of poly(methylmethacrylate)-based composite was studied in vitro. Methods The effect of protein on calcium phosphate formation was followed by ion concentration analyses (ICP), x-ray diffraction (XRD), and scanning electron microscopy coupled with x-ray energy dispersive spectroscopy (SEM-EDS). Results and Conclusions The results showed the precipitation of a calcium phosphate layer on the surface of composites immersed in SBF and SBFA. Further transformation and crystallization of this layer, initially amorphous, appears to be influenced by the presence of albumin.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties · Calcium Carbonate Crystallization and Inhibition
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Centre for Research in Ceramic and Composite Materials (CICECO); Department of Ceramics and Glass Engineering, University of Aveiro, Campus Universitário de Santiago, Aveiro - Portugal
Department of Chemical Engineering, Faculty of Sciences and Technology, University of Coimbra, Coimbra, - Portugal
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