Human Organs‐on‐Chips: A Review of the State‐of‐the‐Art, Current Prospects, and Future Challenges
Source abstract
Abstract
Abstract New emerging technologies, remarkably miniaturized 3D organ models and microfluidics, enable simulation of the real in vitro microenvironment ex vivo more closely. There are many fascinating features of innovative organ‐on‐a‐chip (OOC) technology, including the possibility of integrating semipermeable and/or stretchable membranes, creating continuous perfusion of fluids into microchannels and chambers (while maintaining laminar flow regime), embedding microdevices like microsensors, microstimulators, micro heaters, or different cell lines, along with other 3D cell culture technologies. OOC systems are designed to imitate the structure and function of human organs, ranging from breathing lungs to beating hearts. This technology is expected to be able to revolutionize cell biology studies, personalized precision medicine, drug development process, and cancer diagnosis/treatment. OOC systems can significantly reduce the cost associated with tedious drug development processes and the risk of adverse drug reactions in the body, which makes drug screening more effective. The review mainly focus on presenting an overview of the several previously developed OOC systems accompanied by subjects relevant to pharmacy‐, cancer‐, and placenta‐on‐a‐chip. The challenging issues and opportunities related to these systems are discussed, along with a future perspective for this technology.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Innovative Microfluidic and Catalytic Techniques Innovation · Microfluidic and Bio-sensing Technologies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Chemical Engineering Oklahoma State University 420 Engineering North Stillwater OK 74078 USA
Department of Polymer Technology Faculty of Chemistry Gdańsk University of Technology G. Narutowicza 11/12 Gdańsk 80‐233 Poland
College of Materials Science and Engineering Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials Shenzhen University Shenzhen 518060 China
Center of Excellence in Electrochemistry School of Chemistry, College of Science University of Tehran Tehran 1417466191 Iran
Department of Chemical Engineering Urmia University of Technology Urmia 57166‐419 Iran
Department of Chemical Engineering Tabriz University Tabriz 51335‐1996 Iran
Joint International Research Lab of Lignocellulosic Functional Materials Nanjing Forestry University Nanjing 210037 China
Biosensor Research Center Endocrinology and Metabolism Molecular–Cellular Sciences Institute Tehran University of Medical Sciences Tehran 14395‐1179 Iran
Department of Tissue Engineering & Regenerative Medicine Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran 1449614535 Iran
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