Genistein, a Soybean Isoflavone, Promotes Wound Healing by Enhancing Endothelial Progenitor Cell Mobilization in Rats with Hemorrhagic Shock
Source abstract
Abstract
Abstract Severe trauma and hemorrhaging are often accompanied by delayed cutaneous wound healing. Soybean isoflavone is a natural phytoestrogen that has attracted great attention due to its protective effects against various injuries. Endothelial progenitor cells (EPCs) are precursor cells with directional differentiation characteristics. This study is to determine whether genistein (GEN), an isoflavone in soybean products, benefits wound healing in hemorrhagic shock (HS) rats by promoting EPC homing and to investigate the underlying mechanisms. In this study, it is found that GEN promotes skin wound healing in HS rats, which is due at least partly to the mobilization of endogenous EPCs to the injury site via angiotensin II (Ang‐II), stromal cell‐derived factor‐1alpha (SDF‐1α), and transforming growth factor beta(TGF‐β) signaling.
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Research context
OpenAlex topics: Wound Healing and Treatments · Fatty Acid Research and Health · Seaweed-derived Bioactive Compounds
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Shock and Transfusion Research Institute of Surgery State Key Laboratory of Trauma Burns and Combined Injury Daping Hospital Army Medical University Chongqing 400042 P. R. China
Department of Weapon Bioeffect Assessment Research Institute of Surgery State Key Laboratory of Trauma Burns and Combined Injury Daping Hospital Army Medical University Chongqing 400042 P. R. China
Funding
National Key Research and Development Program of China · National Natural Science Foundation of China
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