Engineering Advanced In Vitro Models of Systemic Sclerosis for Drug Discovery and Development
Source abstract
Abstract
Abstract Systemic sclerosis (SSc) is a complex multisystem disease with the highest case‐specific mortality among all autoimmune rheumatic diseases, yet without any available curative therapy. Therefore, the development of novel therapeutic antifibrotic strategies that effectively decrease skin and organ fibrosis is needed. Existing animal models are cost‐intensive, laborious and do not recapitulate the full spectrum of the disease and thus commonly fail to predict human efficacy. Advanced in vitro models, which closely mimic critical aspects of the pathology, have emerged as valuable platforms to investigate novel pharmaceutical therapies for the treatment of SSc. This review focuses on recent advancements in the development of SSc in vitro models, sheds light onto biological (e.g., growth factors, cytokines, coculture systems), biochemical (e.g., hypoxia, reactive oxygen species) and biophysical (e.g., stiffness, topography, dimensionality) cues that have been utilized for the in vitro recapitulation of the SSc microenvironment, and highlights future perspectives for effective drug discovery and validation.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Systemic Sclerosis and Related Diseases · Mast cells and histamine · Skin and Cellular Biology Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Dr. A. De Pieri, Prof. K. Wuertz‐Kozak Department of Biomedical Engineering Rochester Institute of Technology (RIT) 106 Lomb Memorial Rd. Rochester NY 14623 USA
Prof. B. D. Korman Department of Medicine Division of Allergy Immunology and Rheumatology University of Rochester Medical Center Rochester NY 14623 USA
Prof. A. Jüngel Center of Experimental Rheumatology University Clinic of Rheumatology Balgrist University Hospital University Hospital Zurich Zurich 8008 Switzerland
Prof. A. Jüngel Department of Physical Medicine and Rheumatology Balgrist University Hospital University of Zurich Zurich 8008 Switzerland
Prof. K. Wuertz‐Kozak Schön Clinic Munich Harlaching Spine Center, Academic Teaching Hospital and Spine Research Institute of the Paracelsus Medical University Salzburg (Austria) Munich 81547 Germany
Funding
National Science Foundation · National Institute of Arthritis and Musculoskeletal and Skin Diseases
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