Source abstract
Abstract
Abstract The altered functions of adipose tissue are one of the main issues in obesity. Bariatric surgery is associated with improvement of obesity associated comorbidities. Here DNA methylation remodeling in adipose tissue after bariatric surgery is examined. After six months postoperative, DNA methylation shows changes in 1155 CpG sites, 66 of these sites correlate with body mass index. Some sites also show correlation with LDL‐C, HDL‐C, total cholesterol, and triglycerides. CpG sites are located in genes that have not previously been linked to obesity or metabolic diseases. GNAS complex locus is one of those that presented CpG site with the greatest changes after surgery, and the most significant correlation with BMI and lipid profiles. These results show that epigenetic regulation may be involved in the alteration of adipose tissue functions in obesity.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Epigenetics and DNA Methylation · Bariatric Surgery and Outcomes · Dietary Effects on Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Immunogenomics and Metabolic Disease Laboratory Instituto Nacional de Medicina Genómica SS Periférico Sur 4809 Mexico City Tlalpan 14610 Mexico
Posgrado en Ciencias Biológicas Universidad Nacional Autónoma de México Cto. de los Posgrados, Ciudad Universitaria Mexico City Coyoacán 04510 Mexico
Facultad de Medicina Alta especialidad en Cirugía Bariatrica UNAM Escolar 411A, Copilco Universidad Mexico City Coyoacán 04360 Mexico
Clínica Integral de Obesidad Hospital General Tláhuac Secretaría de Salud de la CDMX Av. La turba 655 Mexico City Tláhuac 13278 Mexico
Funding
Consejo Nacional de Ciencia y Tecnología
References (34)
Show source-provided references
1. Yu S. · BioMed. Res. Int. · 2019 · 2019
6. Milagro F. · Rev. chil. endocrinol. diabetes · 2013 · 6 · 108