Surface modification of PLGA nanofibrous biocomposites using flavonoids for biomedical applications

Rutin-containing poly(L-lactide-co-glycolide) (PLGA) nanofibrous biocomposites were prepared by electrospinning technique and antibacterial properties of the biocomposites were examined. Two types of bacterial strains, Staphylococcus aureus and Klebsiella pneumoniae were used in this test. The results showed that the rutin-containing PLGA nanofibrous biocomposites exhibited significant antibacterial effects against both the bacteria. Human nasopharyngeal epidermoid carcinoma (KB) epithelial cells were used to evaluate cytotoxicity. It was found that there was no cytotoxicity for the rutin-containing PLGA nanofibrous biocomposites.