A novel 3D printed hollow microneedle microelectromechanical system for controlled, personalized transdermal drug delivery
Source abstract
Abstract
The advancement of drug delivery devices is critical for the individualization of patient treatment and the improvement of healthcare. Here, we introduce the 3DMNMEMS, a novel device that combines 3D printing, microneedles (MNs) and Microelectromechanical Systems (MEMS), allowing versatile and controllable by the user transdermal drug delivery. Hollow MNs were designed and 3D printed using Stereolithography, followed by integrating into a MEMS. By employing advanced imaging techniques, we monitored the distribution of liquid delivered by the device within skin tissue in real time. In vivo testing revealed that the delivery of insulin using the 3DMNMEMS achieved improved glycemic control to diabetic animals compared to subcutaneous injections. These results demonstrated the potential of the 3DMNMEMS as a universal transdermal drug delivery system for personalized care.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advancements in Transdermal Drug Delivery · Spectroscopy Techniques in Biomedical and Chemical Research · Ocular Surface and Contact Lens
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. “Personalised medicine” through “personalised medicines”: time to integrate advanced, non-invasive imaging approaches and smart drug delivery systems10.1016/j.ijpharm.2011.02.010 ↗
2. Pharmaceutical applications of 3D printing
3. Shaping the future: recent advances of 3D printing in drug delivery and healthcare10.1080/17425247.2019.1660318 ↗
4. 3D printed antibiotic and chemotherapeutic eluting catheters for potential use in interventional radiology: in vitro proof of concept study10.1016/j.acra.2018.03.022 ↗
5. Development of a biodegradable subcutaneous implant for prolonged drug delivery using 3D printing10.3390/pharmaceutics12020105 ↗
6. 3D printing of drug-loaded thermoplastic polyurethane meshes: a potential material for soft tissue reinforcement in vaginal surgery10.3390/pharmaceutics12010063 ↗
7. 3D printing of personalized thick and perfusable cardiac patches and hearts
8. 3D printing technology in drug delivery: recent progress and application
9. Additively manufactured medical products – the FDA perspective10.1186/s41205-016-0005-9 ↗
10. Transdermal drug delivery10.1038/nbt.1504 ↗
11. Device-assisted transdermal drug delivery10.1016/j.addr.2017.08.009 ↗
12. Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum10.3390/pharmaceutics7040438 ↗
13. Microneedles: a smart approach and increasing potential for transdermal drug delivery system10.1016/j.biopha.2018.10.078 ↗
14. Mini-review: assessing the potential impact of microneedle technologies on home healthcare applications10.3390/medicines5020050 ↗
15. Precise microinjection into skin using hollow microneedles10.1038/sj.jid.5700150 ↗
16. 3D printing applications for transdermal drug delivery10.1016/j.ijpharm.2018.01.031 ↗
17. High-fidelity replication of thermoplastic microneedles with open microfluidic channels10.1038/micronano.2017.34 ↗
18. Two photon polymerization of polymer ceramic hybrid materials for transdermal drug delivery10.1111/j.1744-7402.2007.02115.x ↗
19. Biocompatible 3D printed microneedles for transdermal, intradermal, and percutaneous applications10.1002/adem.202070005 ↗
20. Stereolithography
21. 3D printed microneedles for insulin skin delivery10.1016/j.ijpharm.2018.03.031 ↗
22. 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery10.1016/j.msec.2019.04.063 ↗
23. MEMS devices for drug delivery10.1016/j.addr.2017.11.003 ↗
24. The impact of externally worn diabetes technology on sexual behavior and activity, body image, and anxiety in type 1 diabetes
25. Bioresponsive transcutaneous patches10.1016/j.copbio.2017.03.001 ↗
26. Complex master-slave for long axial range swept-source optical coherence tomography10.1364/OSAC.1.001251 ↗
27. Complex master slave interferometry10.1364/OE.24.002885 ↗
28. A 3D-printed micro fluidic-enabled hollow microneedle architecture for transdermal drug delivery10.1063/1.5127778 ↗
29. Biodegradable 3D printed polymer microneedles for transdermal drug delivery10.1039/C8LC00098K ↗
30. Survey of FDM process parameter optimization and their influence on part characteristics
31. Recent developments in fused deposition modeling-based 3D printing of polymers and their composites10.1080/15583724.2019.1597883 ↗
32. Mechanical characterization of 3D-printed polymers
33. Low cost additive manufacturing of microneedle masters10.1186/s41205-019-0039-x ↗
34. Vertex, Certificate of Biocompatibility, 2016. 〈https://support.formlabs.com/s/article/Certifications-and-standards?language=en_US〉.
35. Evaluation of resins for stereolithographic 3D-printed surgical guides: the response of L929 cells and human gingival fibroblasts10.1155/2017/4057612 ↗
36. 3D printing of cell culture devices: assessment and prevention of the cytotoxicity of photopolymers for stereolithography10.3390/ma13133011 ↗
37. Effect of microneedle design on pain in human subjects10.1097/AJP.0b013e31816778f9 ↗
38. Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force10.1016/j.jbiomech.2003.12.010 ↗
39. In vivo measurements of the elastic mechanical properties of human skin by indentation tests10.1016/j.medengphy.2007.06.011 ↗
40. Microneedles for transdermal drug delivery10.1016/j.addr.2003.10.023 ↗
41. E. Forvi, M. Soncini, M. Bedoni, F. Rizzo, M. Casella, C. O’Mahony, F. Gramatica, A method to determine the margin of safety for microneedles arrays, WCE 2010 - World Congress on Engineering, 2(2010), 2010, 1550–1554.
42. Formlabs, Dental SG Material Properties, 2016.
43. Arrays of hollow out-of-plane microneedles for drug delivery10.1109/JMEMS.2005.844843 ↗
44. Arrays of hollow out-of-plane microneedles made by metal electrodeposition onto solvent cast conductive polymer structures10.1088/0960-1317/23/8/085011 ↗
45. Accuracy and reproducibility of low dose insulin administration using pen-injectors and syringes10.1136/adc.79.1.59 ↗
46. Microinfusion using hollow microneedles10.1007/s11095-005-8498-8 ↗
47. Optical coherence tomography: An emerging technology for biomedical imaging and optical biopsy10.1038/sj.neo.7900071 ↗
48. Optical coherence tomography in biomedical research10.1007/s00216-011-5052-x ↗
49. Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution10.1016/j.jconrel.2010.08.008 ↗
50. Hydrogel-forming microneedles increase in volume during swelling in skin, but skin barrier function recovery is unaffected10.1002/jps.23921 ↗
51. Hollow metal microneedles for insulin delivery to diabetic rats10.1109/TBME.2005.845240 ↗
52. Microfabricated needles for transdermal delivery of macromolecules and nanoparticles : Fabrication methods and transport studies10.1073/pnas.2331316100 ↗