Nano-particles’ benefits for colon cancer effective therapy: a review of recent advancements and clinical trials

A variety of fascinating nanocarriers have reportedly been used and highlighted as novel drug delivery system in human colorectal cancer (CRC) treatment. In this context, significant progress has been achieved in the last few years and a great deal of promising NPs application has been reported as well. According to the literature reviews, the application of different types of NPs improves the efficacy, stability and selectivity of anti-colon cancer drugs. Moreover, the outcome of in vitro and in vivo experiments, also conducted preclinical and clinical investigations, has not only pushed the boundaries of knowledge but also revealed the favorable therapeutic benefits of NPs in CRC therapy more than before. Thus, scientists conclude that it is not surprising if NPs play a crucial role in CRC treatment in the near future. The present review gathers the most recent knowledge of the field, and also addresses a summary of the advancements and clinical trials conducted so far. The authors hope that the present review will provide comprehensive information about the up-to-date results of the recently conducted investigations for those who are willing to read everything at a glance.