journal article·2020-10-12

Hybrid chitosan/amniotic membrane-based hydrogels for articular cartilage tissue engineering application

Tatiane Venturott Toniato, Thiago Domingues Stocco, Danilo dos Santos Martins, Luciana Barros Santanna, Carla Roberta Tim, Fernanda Roberta Marciano, Edson Cavalcanti Silva-Filho, Sérgio Paulo Campana-Filho, Anderson de Oliveira Lobo

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Abstract

A hybrid hydrogel combining collagen and chitosan (Ch) and human amniotic membranes (AM) were produced. To produce hybrid hydrogels, a fixed concentration of chitosan (2%) was used, adding AM as a booster at the concentrations of 2.5, 5.0. and 10.0% (w/w). DSC curves showed the denaturation of collagen. The swelling capacity of hydrogels ranged between 333 ± 19% and 368 ± 28%. The groups Ch-1.0 mg/mL and Ch-2.0 mg/mL had an elastic modulus 27% higher than the other groups.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · Silk-based biomaterials and applications · Collagen: Extraction and Characterization

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Research and Development, University of Vale do Paraiba, São Paulo, Brazil;

Faculty of Medical Sciences, State University of Campinas, São Paulo, Brazil;

Faculty of Physiotherapy, University of Santo Amaro, São Paulo, Brazil;

São Carlos Institute of Chemistry, University of São Paulo, São Paulo, Brazil;

Laboratory of Immunology, University of Vale do Paraiba, São Paulo, Brazil;

Scientific and Technological Institute, Brasil University, São Paulo, Brazil;

Department of Physics, Federal University of Piauí, Teresina, Piauí, Brazil;

LIMAV-Interdisciplinary Laboratory for Advanced Materials, Department of Materials Engineering, UFPI-Federal University of Piauí, Teresina, Piauí, Brazil

Funding

Sao Paulo Research Foundation · National Council for Scientific and Technological Development

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