DataVXInternational Journal of Polymeric Materials and Polymeric BiomaterialsPaper
journal article·2024-03-03

Strontium-doped mesoporous bioactive glass microspheres developed for drug delivering and enhancing the bioactivity of polylactic acid scaffolds

Weixin Chen, Shunyu Chen, Dongzhi Wu, Xing Wu, Tao Zhang, Xiufeng Xiao

International Journal of Polymeric Materials and Polymeric Biomaterials· Volume 73· Issue 4
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Source abstract

Abstract

Strontium-doped mesoporous bioactive glass microspheres (Sr-MBGMs) were prepared by sol–gel method for delivering loxoprofen sodium (LX) drug. The loading capacity of the prepared Sr-MBGMs for LX drug was affected by the initial concentration of the drug solution and adsorption time. The LX-loaded Sr-MBGMs obtained under optimum conditions were coated with polydopamine (LX/Sr-MBGMs@PDA) and incorporated into the aminated modified poly-l-lactic acid nanofibrous matrix to develop a functional composite scaffold for bone tissue engineering applications. The in vitro studies revealed that the incorporation of the LX/Sr-MBGMs@PDA could promote cell proliferation and biomineralization, indicating that the as-developed composite scaffolds possessed an improved cell viability and osteogenic ability.
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Research context

Ceramics & glassesNanomaterialsBiomaterialsComposites

OpenAlex topics: Bone Tissue Engineering Materials · Polymer Surface Interaction Studies · biodegradable polymer synthesis and properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Engineering Research Center of Industrial Biocatalysis, College of Chemistry and Material Science, Fujian Normal University, Fuzhou, China

Department of Orthopedics Institute, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

Department of Orthopedics Institute, Fuzhou Second Hospital, Fuzhou, China

Department of Orthopedics Institute, The Third Clinical Medical College, Fujian Medical University, Fuzhou, China

Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China

Funding

Natural Science Foundation of Fujian Province · Fuzhou Science and Technology Project · Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma · Medical innovation project of Fujian Provincial Health Commission · Fuzhou health innovation platform construction project

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